INT233635

Context Info Confidence 0.66 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.02 Pain Relevance 2.38

cytosol (Zbtb16) plasma membrane (Zbtb16) nucleus (Zbtb16) DNA binding (Zbtb16)

Anatomy Link Frequency finger 1 Zbtb16 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 516 99.72 Opioid 84 80.72 tolerance 24 79.84 withdrawal 27 72.36 adenocard 6 71.00 antagonist 18 70.16 Physical dependence 30 67.08 opiate 12 29.52 depression 3 20.84 addiction 24 5.00

Disease Link Frequency Relevance Heat Apoptosis 24 98.30 Sprains And Strains 246 95.48 Nervous System Malformation 12 93.84 Adhesions 3 81.28 Skin Cancer 3 80.72 Opiate Addiction 24 72.36 Drug Dependence 36 67.08 Respiratory Failure 3 20.84 Hypoxia 3 19.52 Shock 24 16.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The qPCR method was used to evaluate the influence of GR blockade on acute morphine-induced gene transcription of selected genes (Tsc22d3, Nfkbia, Zbtb16, Sgk, and Fzd2).

Transcription (transcription) of Zbtb16 associated with morphine

1) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.30 Pain Relevance 0.91

Increased mRNA abundance of TSC22 domain family 3 (Tsc22d3) and zinc finger and BTB domain containing 16 (Zbtb16) transcripts was found to be positively related to morphine preference (Figure 7).

Transcription (transcripts) of Zbtb16 in finger associated with morphine

2) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.53 Pain Relevance 0.99

Also, genes associated with negative regulation of cellular processes (GO: 0048532; 17 transcripts; P = 0.001) and regulation of apoptosis (GO: 0042981; ten transcripts; P = 0.005) were over-represented, including Sgk3 and Zbtb16 transcripts.

Transcription (transcripts) of Zbtb16 associated with apoptosis

3) Confidence 0.64 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.19 Pain Relevance 0.48

General Comments

This test has worked.