INT233804

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.07

transport (Slc52a2) plasma membrane (Slc52a2)

Slc52a2 (Mus musculus)

Pain Link Frequency Relevance Heat Cannabinoid receptor 4 69.96 Pain 2 15.88 Glutamate 22 5.00 chemokine 14 5.00 Glutamate receptor 4 5.00 Somatostatin 4 5.00 Cannabinoid 4 5.00 Peripheral nervous system 2 5.00 GABA receptor 2 5.00 adenocard 2 5.00

Disease Link Frequency Relevance Heat Pain 2 15.88 Adhesions 70 5.00 Disease 8 5.00 Multiple System Atrophy 8 5.00 Hypercalcemia 4 5.00 Syndrome 2 5.00 Targeted Disruption 2 5.00 Diabetes Insipidus 2 5.00 Chondrodysplasia 2 5.00 Aging 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vertebrate INSL3/relaxin binding GPCRs, a combination of a single cysteine-rich LDL-A domain and multiple LRRs at the ectodomain site is necessary for ligand binding, receptor activation and further downstream signalling from these receptors [45].

GPCR Binding (binding) of

1) Confidence 0.36 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0

These receptors have TM regions that are homologous to vertebrate INSL3/Relaxin binding GPCRs.

GPCR Binding (binding) of

2) Confidence 0.36 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0.07

General Comments

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