INT233867

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.25
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SKP2) cytosol (SKP2) nucleoplasm (SKP2)
SKP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 87.84 High High
agonist 78 82.56 Quite High
Bile 5 42.44 Quite Low
fibrosis 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 99.36 Very High Very High Very High
Mantle-cell Lymphoma 33 91.80 High High
Toxicity 20 82.88 Quite High
Hepatocellular Cancer 42 82.40 Quite High
Bladder Cancer 4 76.32 Quite High
Nash(non-alcoholic Steatohepatitis) 3 70.08 Quite High
Hepatotoxicity 23 58.20 Quite High
Malignant Neoplastic Disease 9 50.72 Quite High
Cancer 61 50.48 Quite High
Lymphatic System Cancer 122 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase occurred through down-regulation of nuclear S-phase kinase-associated protein 2 (SKP2) [80].
Negative_regulation (regulation) of SKP2
1) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.75 Pain Relevance 0.04
inhibitory effect on p27kip1 degradation via inhibition of Skp2, an
Negative_regulation (inhibition) of Skp2
2) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.19 Pain Relevance 0.04
This increase occurred through down-regulation of nuclear S-phase kinase-associated protein 2 (SKP2) [80].
Negative_regulation (regulation) of nuclear S-phase kinase-associated protein 2
3) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.75 Pain Relevance 0.04
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
Negative_regulation (downregulation) of Skp2
4) Confidence 0.20 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.56 Pain Relevance 0

General Comments

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