INT233881

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.68
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
macrophages 2
leukocyte 1
Cd36 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 200 99.92 Very High Very High Very High
Inflammatory mediators 3 97.88 Very High Very High Very High
agonist 50 79.68 Quite High
chemokine 6 75.04 Quite High
Bile 40 49.80 Quite Low
tolerance 26 34.72 Quite Low
cytokine 31 31.28 Quite Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 212 99.92 Very High Very High Very High
Congenital Anomalies 44 97.96 Very High Very High Very High
Apoptosis 33 97.28 Very High Very High Very High
Diabetes Mellitus 42 96.16 Very High Very High Very High
Cerebral Malaria 2 95.04 Very High Very High Very High
Disease 39 93.72 High High
Hemorrhage 2 89.24 High High
Cancer 103 87.04 High High
Colitis 7 86.88 High High
Metabolic Syndrome 22 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both cholesterol efflux and the transcription of efflux-related receptors, namely CD36 and ATP-binding cassette protein A1, were increased by niacin.
Positive_regulation (increased) of CD36
1) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.68 Pain Relevance 0
target genes involved in triglycerides (TG) synthesis such as lipoprotein lipase (Lpl), phosphoenolpyruvate carboxykinase (PEPCK) and CD36 was significantly upregulated in ?
Positive_regulation (upregulated) of CD36
2) Confidence 0.45 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
The increase in CD36 may be relevant to the pathogenesis of behavioral abnormalities and pathology given its role in other conditions including cerebral malaria and Alzheimer's disease [114,115].
Positive_regulation (increase) of CD36 associated with congenital anomalies, disease and cerebral malaria
3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.71 Pain Relevance 0.08
CD36 activation could have consequences in the immune response, favoring leukocyte apoptosis and clearance.(74) In addition, ABT-510 has been proved to induce caspase activation and apoptosis independently of its interaction with CD36.(75)
Positive_regulation (activation) of CD36 in leukocyte associated with apoptosis
4) Confidence 0.33 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.15 Pain Relevance 0.05
contributes to the balance between lipid influx and efflux in macrophages by upregulating target genes (e.g., fatty acid transporters and CD36) [28].

3.

Positive_regulation (upregulating) of CD36 in macrophages
5) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.62 Pain Relevance 0.08
activation by major oxidized lipid components of ox-LDL, 9-HODE and 13-HODE has an important role in the development of lipid-accumulating macrophages through transcriptional induction of CD36, a scavenger receptor
Positive_regulation (induction) of CD36 in macrophages
6) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.54 Pain Relevance 0.04
SXR can mediate a SREBP-independent lipogenic pathway by activating the free fatty acid (FFA) uptake transporter CD36, PPAR?
Positive_regulation (activating) of CD36
7) Confidence 0.15 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0
However, to date, only CD36 upregulation [89] and decreased
Positive_regulation (upregulation) of CD36
8) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396401 Disease Relevance 0.81 Pain Relevance 0.05

General Comments

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