INT233975

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.17
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
bone marrow 4
bile duct 2
brain 2
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 145 100.00 Very High Very High Very High
chemokine 45 100.00 Very High Very High Very High
Inflammation 199 98.88 Very High Very High Very High
Bile 3 98.78 Very High Very High Very High
Inflammatory response 70 78.48 Quite High
Inflammatory stimuli 4 40.68 Quite Low
ischemia 16 20.12 Low Low
Paracetamol 6 19.20 Low Low
Mechanotransduction 18 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 24 99.24 Very High Very High Very High
Hypersensitivity 1 98.08 Very High Very High Very High
Systemic Lupus Erythematosus 61 97.88 Very High Very High Very High
Fibrosis 9 97.00 Very High Very High Very High
Alcoholic Hepatitis 1 96.40 Very High Very High Very High
Gallstones 1 95.24 Very High Very High Very High
Injury 80 92.76 High High
Endotoxemia 4 91.28 High High
INFLAMMATION 224 89.84 High High
Encephalitis 7 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of MyD88 by intrinsic vascular cells was necessary for cytokine and chemokine production and changes in vessel size, whereas MyD88 expression by bone marrow–derived cells was obligatory for changes in vessel size.
Positive_regulation (necessary) of Gene_expression (Expression) of MyD88 in bone marrow associated with chemokine and cytokine
1) Confidence 0.66 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2605224 Disease Relevance 0.31 Pain Relevance 0.27
Expression of MyD88 by intrinsic vascular cells was necessary for cytokine and chemokine production and changes in vessel size, whereas MyD88 expression by bone marrow–derived cells was obligatory for changes in vessel size.
Positive_regulation (necessary) of Gene_expression (expression) of MyD88 in bone marrow associated with chemokine and cytokine
2) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2605224 Disease Relevance 0.30 Pain Relevance 0.27
We used BM reconstitution experiments to characterize which cell types required MyD88 expression for flow-mediated vascular inflammation and inward remodeling.
Positive_regulation (required) of Gene_expression (expression) of MyD88 associated with inflammation and vasculitis
3) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.38 Pain Relevance 0.31
were observed at 10 days in the brain cortex of MPSIIIB mice, but not in MPSIIIB mice deleted for the expression of Toll-like receptor 4 or the adaptor protein MyD88, indicating early priming of microglial cells by heparan sulfate oligosaccharides in the MPSIIIB mouse brain.
Neg (not) Positive_regulation (deleted) of Gene_expression (expression) of MyD88 in brain
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2396504 Disease Relevance 0.85 Pain Relevance 0.21
However, an alternative strategy takes advantage of the fact that all of the TLRs, with the exception of TLR3, as well as many of the early response cytokine receptors utilize the adapter protein, myeloid differentiation factor 88 (MyD88) [25,26].
Positive_regulation (many) of Neg (exception) Gene_expression (utilize) of MyD88 associated with cytokine
5) Confidence 0.42 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.34 Pain Relevance 0.22
However, an alternative strategy takes advantage of the fact that all of the TLRs, with the exception of TLR3, as well as many of the early response cytokine receptors utilize the adapter protein, myeloid differentiation factor 88 (MyD88) [25,26].
Positive_regulation (many) of Neg (exception) Gene_expression (utilize) of myeloid differentiation factor 88 associated with cytokine
6) Confidence 0.42 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.34 Pain Relevance 0.22
Two independent groups have shown that inhibiting MyD88 impairs the phosphorylation/activation of downstream kinases [86] and NF?
Positive_regulation (activation) of Neg (impairs) Gene_expression (impairs) of MyD88
7) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.58 Pain Relevance 0.07
In bile duct-ligated animals, pretreatment with intraperitoneal LPS upregulates the expression of TLR4 and MyD88 [6], as well as CD14 and CD68 [7], and confers hypersensitivity to LPS in fibrotic livers.
Positive_regulation (upregulates) of Gene_expression (expression) of MyD88 in bile duct associated with fibrosis, bile and hypersensitivity
8) Confidence 0.20 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.08 Pain Relevance 0.09

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