INT234057

From wiki-pain
Revision as of 01:13, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.79
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)
Anatomy Link Frequency
neurons 4
brain 2
stem cells 2
Dcx (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 58 92.52 High High
antagonist 8 69.84 Quite High
Inflammation 76 66.28 Quite High
Central nervous system 37 51.16 Quite High
Inflammatory response 10 18.32 Low Low
cINOD 26 5.00 Very Low Very Low Very Low
neurotrophin 3 16 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 188 99.32 Very High Very High Very High
Infection 96 98.80 Very High Very High Very High
Cytomegalovirus Infection 114 93.28 High High
Viral Infection 26 89.76 High High
Injury 14 88.48 High High
Apoptosis 12 85.24 High High
Death 12 83.40 Quite High
INFLAMMATION 90 66.28 Quite High
Sensorineural Hearing Loss 2 45.80 Quite Low
Cerebral Palsy 2 44.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that infection of the developing brain, which is rich in NSCs, results in reduced expression of doublecortin (DCX), a marker that identifies young/immature neurons, while the glial precursor and mature astrocyte marker, glial acidic fibrillary protein (GFAP) expression remained unaltered.
Negative_regulation (reduced) of Gene_expression (expression) of doublecortin in brain associated with infection
1) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.88 Pain Relevance 0.03
Finally, we report decreased expression of doublecortin, a marker to identify young neurons, following viral brain infection.


Negative_regulation (decreased) of Gene_expression (expression) of doublecortin in neurons associated with infection
2) Confidence 0.42 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.27 Pain Relevance 0
The number of newborn neurons expressing Dcx was decreased in the DG of bigenic-Dox mice (Figures 3D & 3E; t10?
Negative_regulation (decreased) of Gene_expression (expressing) of Dcx in neurons
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.34 Pain Relevance 0
The increased number of neurons resulted from changes in proliferation of Sox2-positive neural stem cells [21] and nestin-positive precursor cells [22], an effect that led to increased numbers of Dcx expressing neuroblasts and neurogenesis.
Negative_regulation (numbers) of Gene_expression (expressing) of Dcx in stem cells associated with neurodegenerative disease
4) Confidence 0.17 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox