INT234057

Context Info Confidence 0.57 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.79 Pain Relevance 0.21

cell differentiation (Dcx) intracellular (Dcx) cytoplasm (Dcx)

Anatomy Link Frequency neurons 4 brain 2 stem cells 2 Dcx (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 58 92.52 antagonist 8 69.84 Inflammation 76 66.28 Central nervous system 37 51.16 Inflammatory response 10 18.32 cINOD 26 5.00 neurotrophin 3 16 5.00 cytokine 14 5.00 long-term potentiation 5 5.00 Eae 5 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 188 99.32 Infection 96 98.80 Cytomegalovirus Infection 114 93.28 Viral Infection 26 89.76 Injury 14 88.48 Apoptosis 12 85.24 Death 12 83.40 INFLAMMATION 90 66.28 Sensorineural Hearing Loss 2 45.80 Cerebral Palsy 2 44.52

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We also show that infection of the developing brain, which is rich in NSCs, results in reduced expression of doublecortin (DCX), a marker that identifies young/immature neurons, while the glial precursor and mature astrocyte marker, glial acidic fibrillary protein (GFAP) expression remained unaltered.

Negative_regulation (reduced) of Gene_expression (expression) of doublecortin in brain associated with infection

1) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.88 Pain Relevance 0.03

Finally, we report decreased expression of doublecortin, a marker to identify young neurons, following viral brain infection.

Negative_regulation (decreased) of Gene_expression (expression) of doublecortin in neurons associated with infection

2) Confidence 0.42 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.27 Pain Relevance 0

The number of newborn neurons expressing Dcx was decreased in the DG of bigenic-Dox mice (Figures 3D & 3E; t10?

Negative_regulation (decreased) of Gene_expression (expressing) of Dcx in neurons

3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.34 Pain Relevance 0

The increased number of neurons resulted from changes in proliferation of Sox2-positive neural stem cells [21] and nestin-positive precursor cells [22], an effect that led to increased numbers of Dcx expressing neuroblasts and neurogenesis.

Negative_regulation (numbers) of Gene_expression (expressing) of Dcx in stem cells associated with neurodegenerative disease

4) Confidence 0.17 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.18

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