INT234293

Context Info Confidence 0.45 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.31 Pain Relevance 0.38

transport (Gria4) plasma membrane (Gria4)

Anatomy Link Frequency thalamus 2 Gria4 (Mus musculus)

Pain Link Frequency Relevance Heat Thalamus 26 99.28 Glutamate 4 98.32 GABA receptor 2 91.32 antagonist 2 90.16 agonist 2 89.52 cerebral cortex 8 33.44 Glutamate receptor 8 5.00 Action potential 8 5.00 midbrain 4 5.00 tetrodotoxin 2 5.00

Disease Link Frequency Relevance Heat Convulsion 10 93.32 Sprains And Strains 40 85.12 Absence Epilepsy 30 80.08 Ataxia 10 50.80 Targeted Disruption 18 50.00 Epilepsy 4 5.00 Congenital Anomalies 4 5.00 Generalized Epilepsy 4 5.00 Death 2 5.00 Dislocations 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, in mice with greatly reduced Gria4 expression, the AMPA receptor composition would change in the reticular thalamus, resulting in the observed changes to AMPA receptor function.

Regulation (change) of Gene_expression (expression) of Gria4 in thalamus associated with thalamus

1) Confidence 0.45 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.31 Pain Relevance 0.30

This overall effect is especially due to a decrease in the number of brief, large-amplitude events (Fig. 5C1–C3), consistent with altered GluR4 receptor expression.

Regulation (altered) of Gene_expression (expression) of GluR4 receptor

2) Confidence 0.27 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0 Pain Relevance 0.07

General Comments

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