INT234462

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.99
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 19 63.16 Quite High
alcohol 2 60.64 Quite High
Inflammation 60 26.08 Quite Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 52 98.28 Very High Very High Very High
Lung Cancer 2 80.92 Quite High
Blast Crisis 1 75.88 Quite High
Chronic Myeloid Leukemia 1 75.36 Quite High
Cancer 192 75.20 Quite High
Chronic Lymphoid Leukemia 1 74.04 Quite High
Skin Cancer 4 64.44 Quite High
Neuroblastoma 2 36.32 Quite Low
Prostate Cancer 1 26.88 Quite Low
INFLAMMATION 62 26.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IHC was done using commercially available mouse monoclonal antibodies directed against human ERBB2, FOXA1, phosphorylated ERBB2 (pERBB2), IGF1R, and EGFR (Additionnal file 1-Table S2).
Phosphorylation (phosphorylated) of IGF1R
1) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0 Pain Relevance 0.03
Expression of ERBB2, phosphorylated ERBB2, EGFR, IGF1R and FOXA1 proteins was assessed by immunohistochemistry to evaluate the functional ERBB2 status and identify co-expressions.


Phosphorylation (phosphorylated) of IGF1R
2) Confidence 0.32 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2958950 Disease Relevance 0.23 Pain Relevance 0
ligand also blocks phosphorylation of other member of RTKs, such as IGF-1R,
Phosphorylation (phosphorylation) of IGF-1R
3) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.76 Pain Relevance 0.03

General Comments

This test has worked.

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