INT234574

Context Info Confidence 0.21 First Reported 2008 Last Reported 2008 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

mitochondrion (POLRMT) DNA binding (POLRMT) nucleotidyltransferase activity (POLRMT)

POLRMT (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 2 5.00

Disease Link Frequency Relevance Heat Mitochondrial Disorders 18 5.00 Disease 16 5.00 Leber Hereditary Optic Atrophy 10 5.00 Diabetes Mellitus 6 5.00 Aging 4 5.00 Deafness 4 5.00 Encephalopathy 2 5.00 Coronary Heart Disease 2 5.00 Syndrome 2 5.00 Renal Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is, therefore, possible that this mechanism blocking mitochondrial RNA-polymerase (mtRPOL) activity is also able to reduce the accuracy of DNA-polymerase ?.

Spec (possible) Negative_regulation (blocking) of mtRPOL

1) Confidence 0.21 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2409300 Disease Relevance 0 Pain Relevance 0

It is, therefore, possible that this mechanism blocking mitochondrial RNA-polymerase (mtRPOL) activity is also able to reduce the accuracy of DNA-polymerase ?.

Spec (possible) Negative_regulation (blocking) of mitochondrial RNA-polymerase

2) Confidence 0.21 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2409300 Disease Relevance 0 Pain Relevance 0

General Comments

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