INT234599

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.44

cytoplasm (Cpox, Ptgds) isomerase activity (Ptgds) transport (Ptgds) mitochondrion (Cpox) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds)

Cpox (Mus musculus) Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat COX-2 inhibitor 4 100.00 Inflammation 21 98.56 Paracetamol 1 64.88 cytokine 19 60.00 chemokine 8 58.88 Inflammatory response 6 53.20 Multiple sclerosis 1 35.84 rheumatoid arthritis 1 25.20 Central nervous system 8 5.00 cINOD 4 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 35 98.56 Hepatotoxicity 1 65.80 Ocular & Orbital Inflammation 1 62.88 Convulsion 1 58.20 Drug Induced Neurotoxicity 3 46.64 Parkinson's Disease 1 41.08 Neurological Disease 1 38.48 Demyelinating Disease 1 35.84 Disease 3 32.96 Familial Adenomatous Polyposis 1 26.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, Gilroy and colleagues demonstrated that selective COX-2 inhibitors, by blocking the production of PGE2 and PGD2, disturbed the resolution phase of inflammation, leading to delay in return to homeostasis [50].

COX Negative_regulation (blocking) of Gene_expression (production) of PGD2 associated with inflammation and cox-2 inhibitor

1) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.60 Pain Relevance 0.44

General Comments

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