INT234605

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr4, Gopc) cytoplasm (Tlr4, Gopc) transport (Gopc)
signal transduction (Tlr4) Golgi apparatus (Gopc) intracellular (Tlr4)
Tlr4 (Mus musculus)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 2 84.40 Quite High
Inflammation 40 76.48 Quite High
cytokine 20 45.28 Quite Low
chemokine 9 44.16 Quite Low
imagery 2 35.96 Quite Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 10 78.16 Quite High
INFLAMMATION 55 76.48 Quite High
Toxicity 1 7.44 Low Low
Parkinson's Disease 32 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS markedly increased the expression of GFAP (Fig. 2A) and SRA mRNA (Fig. 2B) compared to vehicle injected mice, and the induction was higher in COX-2-/- than in COX-2+/+ mice.
LPS Positive_regulation (increased) of Gene_expression (expression) of Fig
1) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0 Pain Relevance 0.04
In addition, FLZ significantly attenuated LPS-induced ROS production including extracellular superoxide (Fig. 5G) and intracellular ROS (Fig. 5H).


LPS Positive_regulation (induced) of Gene_expression (production) of Fig
2) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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