INT234614

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.85
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
MICs 1
stem cell 1
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 8 90.12 High High
abdominal pain 5 78.28 Quite High
Dismenorea 16 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Stromal Tumor 441 99.58 Very High Very High Very High
Leukemia 8 97.84 Very High Very High Very High
Necrosis 5 96.16 Very High Very High Very High
Disease 260 95.08 Very High Very High Very High
Disease Progression 48 92.88 High High
Cancer 217 92.16 High High
Recurrence 34 82.68 Quite High
Leiomyosarcoma 6 82.12 Quite High
Asthenia 4 78.80 Quite High
Abdominal Pain 5 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of the KIT-ligand (stem cell factor) to KIT-RTK results in homodimerization and autophosphorylation of the RTK with subsequent kinase activation.
Phosphorylation (autophosphorylation) of KIT-RTK in stem cell
1) Confidence 0.78 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.23 Pain Relevance 0.05
Rubin et al., [14] demonstrated that, even in GISTs that lacked sequence mutations, KIT was highly phosphorylated.
Phosphorylation (phosphorylated) of KIT
2) Confidence 0.70 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.58 Pain Relevance 0
Preclinical data demonstrate that KIT kinase is inhibited in patients with imatinib-responsive GIST but reactivation of KIT and subsequent downstream phosphorylation occurs at the time of secondary resistance.
Phosphorylation (phosphorylation) of KIT associated with gastrointestinal stromal tumor
3) Confidence 0.68 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.99 Pain Relevance 0.08
Phosphorylation of specific tyrosine residues on KIT triggers a cascade of secondary signaling events and activation of downstream pathways.
Phosphorylation (Phosphorylation) of KIT
4) Confidence 0.68 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.16 Pain Relevance 0.04
In contrast, KIT signaling in primary imatinib-resistant GIST shows no evidence of inhibition to imatinib and is similar to that seen in untreated GIST, indicating that KIT primary resistance is associated with persistent KIT phosphorylation and activation of downstream pathways.37 The molecular mechanisms responsible for primary-imatinib resistance differ from those of secondary resistance.
Phosphorylation (phosphorylation) of KIT associated with gastrointestinal stromal tumor
5) Confidence 0.68 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.84 Pain Relevance 0.07
The appearance, number and location of the cells that we identified by staining for unphosphorylated connexin 43 and c-kit correspond most probably with MICs.
Phosphorylation (unphosphorylated) of c-kit
6) Confidence 0.55 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
Single stain immunohistochemical and double stain immunofluorescence techniques visualised antibodies directed against total connexin 43, unphosphorylated connexin 43, KIT, alpha-SMA and prolyl 4-hydroxylase in myometrial biopsies from 26 women representing all stages of reproductive life.


Phosphorylation (unphosphorylated) of KIT
7) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
Double-stain immunofluorescence for unphosphorylated connexin 43 and KIT, an established marker for interstitial cells, revealed a complete match indicating these cells are myometrial interstitial cells (MICs).
Phosphorylation (unphosphorylated) of KIT in MICs
8) Confidence 0.37 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
A similar double staining procedure was performed on slides from the same biopsies using antibodies to unphosphorylated connexin 43 and KIT (Dilution 1/20).
Phosphorylation (unphosphorylated) of KIT
9) Confidence 0.37 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.06 Pain Relevance 0

General Comments

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