INT234761

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.18
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
IL13 (Homo sapiens)
IL13 - R130Q (1)
Pain Link Frequency Relevance Heat
cytokine 342 94.08 High High
Inflammation 124 91.92 High High
corticosteroid 15 85.92 High High
Inflammatory marker 2 81.56 Quite High
tolerance 2 81.24 Quite High
cva 1 63.44 Quite High
metalloproteinase 2 62.84 Quite High
endometriosis 1 49.80 Quite Low
Inflammatory response 19 46.96 Quite Low
fibrosis 6 35.76 Quite Low
Disease Link Frequency Relevance Heat
Disease 33 99.80 Very High Very High Very High
Occupational Lung Diseases 5 99.54 Very High Very High Very High
Myocardial Infarction 51 99.34 Very High Very High Very High
Asthma 76 98.52 Very High Very High Very High
Reprotox - General 3 27 93.72 High High
INFLAMMATION 146 91.92 High High
Rhinitis 10 91.40 High High
Eosinophilia 2 90.48 High High
Hypersensitivity 33 89.48 High High
Chlamydia Infection 28 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In future studies we will investigate whether MI patients will show a concurrent association with the IL13 R130Q mutation, raised IL-13 activity as well as raised IgE.
IL13 (R130Q) Binding (association) of associated with myocardial infarction
1) Confidence 0.35 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570578 Disease Relevance 1.09 Pain Relevance 0.17
CAT-354 is a high affinity, human monoclonal IgG4 antibody that specifically binds to and neutralises IL-13.
IL-13 Binding (binds) of
2) Confidence 0.30 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 0.77 Pain Relevance 0.29
The intraindividual variablility of serum IL13 in asymptomatic asthmatics (whom had no apparent association between serum IL13 and disease) was up to threefold over a 15-day period (St Ledger et al., 2009).
IL13 Neg (no) Binding (association) of associated with disease and occupational lung diseases
3) Confidence 0.22 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.33 Pain Relevance 0.33
Lebrikizumab is a humanized monoclonal antibody that binds to IL-13 and is currently in development for asthma (ClinicalTrials.gov Identifier: NCT00930163).
IL-13 Binding (binds) of associated with asthma
4) Confidence 0.20 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.63 Pain Relevance 0
In our study, IL-4 was undetectable and IL-13 levels were not significantly different in any group in contrast to previous report in which cHSP60 specific IL-13 in PBMCs has been reported to be associated with the protective response [22].
IL-13 Binding (associated) of
5) Confidence 0.03 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 0.78 Pain Relevance 0.29
The biological effects of IL-13 may be achieved through binding to the IL-4 receptor ?
IL-13 Binding (binding) of
6) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.58 Pain Relevance 0.48

General Comments

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