INT234882

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acantholysis 130 93.68 High High
Bullous Skin Disease 608 77.36 Quite High
Disease 36 10.16 Low Low
Apoptosis 38 6.92 Low Low
Adhesions 102 5.00 Very Low Very Low Very Low
Blister 24 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low
Skin Diseases 10 5.00 Very Low Very Low Very Low
Heart Defects 8 5.00 Very Low Very Low Very Low
Skin Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, phosphorylation of Dsg 3 was observed in some studies but not in others, which might be due to different cell culture models indicating that Dsg phosphorylation is not necessary for acantholysis (Chernyavsky et al. 2007b; Nguyen et al. 2004a).
Phosphorylation (phosphorylation) of Dsg 3 associated with acantholysis
1) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.36 Pain Relevance 0
Because depletion of Dsg 3 was first found in parallel with serine phosphorylation of Dsg 3, it was suggested that phosphorylation might be required for Dsg 3 degradation (Aoyama and Kitajima 1999; Aoyama et al. 1999; Bystryn and Rodriguez 1978; Rodriguez and Bystryn 1977).
Phosphorylation (phosphorylation) of Dsg 3
2) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.24 Pain Relevance 0

General Comments

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