INT234898

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.92
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
CAR 2
cardiomyocytes 2
keratinocyte 2
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 50.04 Quite High
imagery 4 8.80 Low Low
Kinase C 52 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 204 100.00 Very High Very High Very High
Disease 72 99.48 Very High Very High Very High
Bullous Skin Disease 1216 98.96 Very High Very High Very High
Acantholysis 260 98.72 Very High Very High Very High
Hepatitis A Virus Infection 4 90.72 High High
Cv General 4 Under Development 4 88.40 High High
Embryonic Lethality 12 87.36 High High
Skin Diseases 20 78.24 Quite High
Vohwinkel Syndrome 24 76.56 Quite High
Autoimmune Disease 16 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One explanation is that reduced expression of desmosomal components in hyperproliferating cells may foster the loss of keratinocyte cohesion in pemphigus.
Negative_regulation (reduced) of Gene_expression (expression) of desmosomal in keratinocyte associated with bullous skin disease
1) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.44 Pain Relevance 0
However, fibrofatty transdifferentiation of cardiomyocytes cannot be simply explained by impaired desmosomal adhesion, but rather seems to be caused by altered wnt/ ?
Negative_regulation (impaired) of Gene_expression (adhesion) of desmosomal in cardiomyocytes associated with adhesions
2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.10 Pain Relevance 0
Peptides derived from these sequences were able to block homophilic adhesion mediated by Dsg 1 and Dsc 1 and to inhibit desmosomal adhesion in epithelial cells when the peptides for Dsg 1 and Dsc 1 were applied together, indicating that the CAR site in the EC 1 domain is critical for maintenance of desmosmal adhesion (Runswick et al. 2001; Tselepis et al. 1998).
Negative_regulation (inhibit) of Gene_expression (adhesion) of desmosomal in CAR associated with adhesions
3) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.68 Pain Relevance 0
Several diseases have been found in which impaired desmosomal adhesion contributes to pathogenesis.
Negative_regulation (impaired) of Gene_expression (adhesion) of desmosomal associated with disease and adhesions
4) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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