INT234905

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2 85.60 High High
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 608 95.20 Very High Very High Very High
Acantholysis 130 71.00 Quite High
Adhesions 102 69.44 Quite High
Hepatitis A Virus Infection 2 51.92 Quite High
Disease 36 43.08 Quite Low
Apoptosis 38 39.84 Quite Low
Blister 24 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low
Skin Diseases 10 5.00 Very Low Very Low Very Low
Heart Defects 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the recent finding that AK 23 similar to Dsg 3 antibodies from PV patients, which are known to be also primarily directed against the N-terminal part of EC 1 (Sekiguchi et al. 2001), is able to directly interfere with Dsg 3 binding (Heupel et al. 2007), these data demonstrate that interaction of EC 1 is crucial for Dsg 3 binding.
Positive_regulation (crucial) of Dsg 3 associated with bullous skin disease
1) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.49 Pain Relevance 0.04
After 24 h, Dsg 3 but not Dsg 2, plakoglobin or desmoplakin was also depleted from the cytoskeletal fractions leading to reduced total cellular Dsg 3 levels (Calkins et al. 2006; Yamamoto et al. 2007a).
Positive_regulation (leading) of Dsg 3
2) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.24 Pain Relevance 0

General Comments

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