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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
dentate gyrus 2
nucleus 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 12 94.56 High High
addiction 2 62.08 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 100.00 Very High Very High Very High
Bullous Skin Disease 304 83.72 Quite High
Disease 106 83.36 Quite High
Sprains And Strains 5 81.60 Quite High
Adhesions 51 77.68 Quite High
Neurodegenerative Disease 12 76.28 Quite High
Disease Progression 2 64.72 Quite High
Autoimmune Disease 4 52.32 Quite High
Affective Disorder 1 45.04 Quite Low
Carcinoma 1 40.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, taking into account all these data it seems that GSK-3 could have different functions in different neurons and in different regions of the brain, while the hippocampal dentate gyrus seems to be more susceptible to degeneration in transgenic mice overexpressing GSK-3?
Positive_regulation (susceptible) of Protein_catabolism (degeneration) of GSK-3 in dentate gyrus associated with targeted disruption
1) Confidence 0.33 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.90 Pain Relevance 0.05
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).

Positive_regulation (dependent) of Protein_catabolism (degradation) of GSK3 in nucleus
2) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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