INT234931

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
nucleus 1
skin 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 60.84 Quite High
agonist 15 50.80 Quite High
antagonist 3 28.56 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 912 99.14 Very High Very High Very High
Acantholysis 195 94.20 High High
Disease 54 84.56 Quite High
Adhesions 153 78.88 Quite High
Autoimmune Disease 12 53.52 Quite High
Apoptosis 57 52.32 Quite High
Carcinoma 3 41.84 Quite Low
Skin Cancer 3 40.32 Quite Low
Breast Cancer 3 35.60 Quite Low
Cancer 9 25.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because pharmacologic inhibition of c-Myc as well as of plakoglobin degradation by blocking GSK 3 abrogated pemphigus-IgG-induced skin blistering, these results indicate that this mechanism could also be important to induce acantholysis.
Protein_catabolism (degradation) of plakoglobin in skin associated with acantholysis and bullous skin disease
1) Confidence 0.29 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.20 Pain Relevance 0.03
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Protein_catabolism (degradation) of plakoglobin in nucleus
2) Confidence 0.29 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.43 Pain Relevance 0.03
Within 30–60 min, PV-IgG induced internalization and lysosomal degradation of cytoskeleton-unbound Dsg 3 together with plakoglobin (Aoyama and Kitajima 1999; Aoyama et al. 1999; Calkins et al. 2006; Sato et al. 2000; Williamson et al. 2006; Yamamoto et al. 2007a).
Protein_catabolism (degradation) of plakoglobin associated with bullous skin disease
3) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.59 Pain Relevance 0

General Comments

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