INT235160

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atxn7) intracellular (Atxn7) cytoplasm (Atxn7)
Atxn7 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 10 72.96 Quite High
Migraine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 66 100.00 Very High Very High Very High
Retina Disease 6 99.00 Very High Very High Very High
Neurological Disease 2 85.16 High High
Cerebellar Ataxia 6 80.80 Quite High
Disease 56 78.52 Quite High
Genetic Anticipation 2 77.60 Quite High
Spinocerebellar Ataxia Type 2 34 77.48 Quite High
Ocular Toxicity (including Many Sub-types) 4 65.16 Quite High
Death 4 63.56 Quite High
Apoptosis 2 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice expressing mutant human ataxin-7 show nuclear inclusions of ubiqutinated ataxin-7 protein that recruits subunits of proteases and chaperons.
Gene_expression (expressing) of ataxin-7
1) Confidence 0.56 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.89 Pain Relevance 0.04
The source of the mutation in many genetic subtypes of ataxias (SCA1, SCA2, SCA3, SCA6, SCA7, SCA12, and SCA17) is the same (CAG repeat expansion), and the resulting protein product contains a long polyglutamine domain.
Gene_expression (source) of SCA7 associated with ataxia
2) Confidence 0.50 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 1.11 Pain Relevance 0

General Comments

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