INT235399

Context Info Confidence 0.15 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.08 Pain Relevance 2.33

plasma membrane (PTGDR) signal transducer activity (PTGDR)

Anatomy Link Frequency basal ganglia 2 PTGDR (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 25 100.00 Opioid 5 99.18 imagery 33 98.16 narcan 3 94.80 Pain 126 92.84 antidepressant 19 90.40 Nucleus accumbens 26 87.08 5HT 141 84.88 rapifen 1 84.48 Analgesic 19 84.04

Disease Link Frequency Relevance Heat Anxiety Disorder 89 98.86 Pain 155 92.84 Tics 1 92.56 Hyperalgesia 4 90.52 Congenital Anomalies 9 43.56 Post-traumatic Stress Disorder 2 38.00 Sleep Disorders 3 31.08 Disease 11 26.24 Headache 1 18.84 Burning Mouth Syndrome 1 12.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Opioids may produce changes in the BG including increases in D2 receptor binding [88].

Positive_regulation (increases) of D2 receptor Binding (binding) of associated with opioid

1) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2883978 Disease Relevance 0.42 Pain Relevance 1.82

Second, a disturbance in dopaminergic function seems to be observed in OCD, as supported by recent neuroimaging studies showing an increase in dopamine transporter binding along with lowered levels of dopaminergic D2 receptor binding in the basal ganglia of patients with OCD (Kim et al 2003; Denys et al 2004).

Positive_regulation (increase) of D2 receptor Binding (binding) of in basal ganglia associated with dopamine and anxiety disorder

2) Confidence 0.03 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.66 Pain Relevance 0.51

General Comments

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