INT235510

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.67
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 3
muscle 1
fibroblasts 1
eosinophils 1
keratinocytes 1
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 268 100.00 Very High Very High Very High
Inflammation 222 100.00 Very High Very High Very High
psoriasis 65 99.78 Very High Very High Very High
rheumatoid arthritis 565 99.56 Very High Very High Very High
Angina 4 97.96 Very High Very High Very High
Multiple sclerosis 21 94.88 High High
Osteoarthritis 51 92.28 High High
chemokine 38 90.56 High High
addiction 1 85.12 High High
imagery 2 80.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 224 100.00 Very High Very High Very High
Disease 222 100.00 Very High Very High Very High
Psoriasis 78 99.78 Very High Very High Very High
Rheumatoid Arthritis 565 99.56 Very High Very High Very High
Syndrome 11 99.30 Very High Very High Very High
Cv General 3 Under Development 4 97.96 Very High Very High Very High
Asthma 105 97.84 Very High Very High Very High
Skin Diseases 3 97.76 Very High Very High Very High
Myocardial Infarction 5 96.56 Very High Very High Very High
Lifespan 3 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously identified IL-17-producing T cells within SF and synovial tissue, and demonstrated that RA synovial fibroblasts treated with IL-17 and TNF?
IL-17 Binding (treated) of in fibroblasts associated with rheumatoid arthritis
1) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.89 Pain Relevance 0.46
There is no doubt that cytokines associated with the Th17 lineage, such as IL-17, IL-6, IL-1?
IL-17 Binding (associated) of associated with cytokine
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.81 Pain Relevance 0.33
To determine the effect of IL-17 on muscle contractility, jejunum longitudinal muscle isolated from normal mice was preincubated with IL-17 (0.1–10 ng/mL) for 2 days and then stimulated by 10?
IL-17 Binding (preincubated) of in muscle
3) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.30 Pain Relevance 0.12
Although the percentage of IL-17-producing CD4 T cells coexpressing TNF?
IL-17-producing Binding (percentage) of in T cells
4) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.22 Pain Relevance 0.07
Salivary gland biopsy specimens from SS patients revealed strong positive staining for both IL-17 and IL-23 within lymphocytic foci and diffuse staining on epithelial tissues.
IL-17 Binding (staining) of in Salivary gland associated with syndrome
5) Confidence 0.29 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.26 Pain Relevance 0.15
In the RA patients there is no report that analyzes miRNAs associated with IL-17 producing T cells.
IL-17 Binding (associated) of in T cells associated with rheumatoid arthritis
6) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.09 Pain Relevance 0.37
The authors demonstrated that IL-23 in combination with IL-17A and IL-17F promoted the production of CXCL1 and IL-8 in human eosinophils generating a strong neutrophilotactic signal, whereas IL-23 together with IL-17F alone induced the production of IL-1?
IL-17A Binding (combination) of in eosinophils
7) Confidence 0.12 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.81 Pain Relevance 0.05
As shown in Fig. 3B the percentage of CD4+ T cells producing IL-17 was significatively augmented with high doses of immobilized anti-CD3 mAb.
IL-17 Binding (augmented) of in T cells
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.23 Pain Relevance 0
The production of CCL-20 is potently induced by synergistic interactions of the inflammatory cytokines TNF, IL-1 and IL-17 [29].
IL-17 Binding (interactions) of associated with inflammation and cytokine
9) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.53 Pain Relevance 0.64
IL-17 is recognized to be the one of the important factors in RA pathogenesis.
IL-17 Binding (recognized) of associated with rheumatoid arthritis
10) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.14 Pain Relevance 0.55
and IL-17, indicating that both Th1 and Th17 immune responses were elicited (Figure 4B).
IL-17 Binding (indicating) of
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.40 Pain Relevance 0
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
IL-17 Binding (induce) of in keratinocytes associated with chemokine, psoriasis and cytokine
12) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.06 Pain Relevance 0.45
its cytokines (IL-17, IL-6, and IL-23) and transcription factor (RORgammat)
IL-17 Binding (cytokines) of associated with cytokine
13) Confidence 0.05 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.94 Pain Relevance 0.48
Exploratory medical studies, however, not only support IL-17A's disease association, but implicate IL-17A's correlation with poor disease prognosis.
IL-17A Binding (association) of associated with disease
14) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 1.00 Pain Relevance 0.31

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