INT235587

Context Info Confidence 0.43 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.62 Pain Relevance 0

intracellular (ITSN2) cytoplasm (ITSN2)

ITSN2 (Homo sapiens)

Pain Link Frequency Relevance Heat isoflurane 8 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 348 99.70 Sleep Initiation And Maintenance Disorders 4 87.08 Stress 8 75.24 Muscle Hypotonia 8 5.00 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, SWA in drowsiness also showed a declining trend across the nocturnal period similar to that seen in SWS, suggesting that in both states SWA is homeostatically regulated.

Regulation (regulated) of SWA associated with sleep disorders

1) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.60 Pain Relevance 0

Spectral analysis of the EEG following sleep deprivation also revealed changes in the SWA consistent with results described in mammals.

Regulation (changes) of SWA associated with sleep disorders

2) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.72 Pain Relevance 0

Thus, SWA changes during baseline sleep mimic those seen in rodents and other mammals, i.e.

Regulation (changes) of SWA

3) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.78 Pain Relevance 0

Figure 5C shows the build-up of SWA during the first 2 hours after sleep onset at higher temporal resolution, i.e. by plotting SWA values in 10-min intervals.

Regulation (values) of SWA

4) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.