INT235758

Context Info Confidence 0.49 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.16 Pain Relevance 0.17

protein complex (Tradd) cytoplasm (Tradd)

Tradd (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 27 99.56 ischemia 86 62.96 Inflammation 12 5.00 cerebral cortex 9 5.00 Intracerebroventricular 9 5.00 medulla 9 5.00 cva 9 5.00 alcohol 6 5.00 metalloproteinase 6 5.00 Hippocampus 6 5.00

Disease Link Frequency Relevance Heat Injury 74 99.52 Stress 11 99.28 Targeted Disruption 129 86.72 Apoptosis 88 78.00 Death 93 74.92 Necrosis 11 73.96 Cancer 11 73.60 Brain Hemorrhage 51 64.16 Middle Cerebral Artery Infarction 93 59.60 Optic Nerve Injuries 34 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

enhanced expression of TRADD protein without ischemic stress, we sampled cortical tissue from the normally-perfused hemisphere in ischemic animals and found that TRADD was nearly threefold higher in the TNF?

Positive_regulation (enhanced) of Gene_expression (expression) of TRADD protein associated with stress

1) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.54 Pain Relevance 0.07

The levels of TRADD protein also increased after both injuries in our study.

Positive_regulation (increased) of Gene_expression (levels) of TRADD associated with injury

2) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.05 Pain Relevance 0

After 3 hours of post-ischemic reperfusion, mean TRADD expression in TNF?

Positive_regulation (mean) of Gene_expression (expression) of TRADD

3) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.28 Pain Relevance 0.05

Regional expression of TRADD protein was uniformly higher in TNF?

Positive_regulation (higher) of Gene_expression (expression) of TRADD protein

4) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.29 Pain Relevance 0.05

General Comments

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