INT23611

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Context Info
Confidence 0.66
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 3.57
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
dorsal 2
bands 2
sensory neurons 1
spinal cord 1
nociceptors 1
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 10 100.00 Very High Very High Very High
unmyelinated 60 99.84 Very High Very High Very High
nociceptor 291 99.76 Very High Very High Very High
Neuropeptide 4 99.76 Very High Very High Very High
qutenza 388 99.74 Very High Very High Very High
Calcitonin gene-related peptide 65 99.30 Very High Very High Very High
Dorsal horn 69 99.20 Very High Very High Very High
Spinal cord 57 97.68 Very High Very High Very High
Sciatic nerve 43 97.36 Very High Very High Very High
Hippocampus 105 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 12 100.00 Very High Very High Very High
Vasculitis 2 99.88 Very High Very High Very High
Injury 87 98.84 Very High Very High Very High
Body Weight 40 97.34 Very High Very High Very High
Anxiety Disorder 8 96.84 Very High Very High Very High
Neointima 11 90.28 High High
Ganglion Cysts 29 89.92 High High
Shock 34 85.64 High High
INFLAMMATION 34 85.04 High High
Hyperalgesia 217 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This strongly suggests that mTOR was not present in unmyelinated C- fibers which often penetrate the epidermis.
Neg (not) Gene_expression (present) of mTOR in epidermis associated with unmyelinated
1) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.08
In addition, we found that pre- or post-training administration of function-blocking anti-BDNF antibodies into dorsal CA1 hampered IA LTM retention, abolished the learning-induced biphasic activation of mTOR and its readout, p70S6K and blocked GluR1 expression, indicating that BDNF is an upstream factor controlling mTOR signaling during fear-memory consolidation.
Gene_expression (expression) of mTOR in dorsal associated with anxiety disorder
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.10 Pain Relevance 0.04
In considering the role of local protein synthesis in synaptic plasticity underlying memory processing [21], [62], [63], the present results raise several questions: What are the upstream extracellular signals that mediate activation of mTOR signaling required for memory formation?
Gene_expression (signaling) of mTOR
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.09
Single or double bands of appropriate molecular weight were found for mTOR, phospho-mTOR, phospho-S6K, phospho-4E-BP1/2 and phospho-S6.


Gene_expression (/) of mTOR in bands
4) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.04
Single or double bands of appropriate molecular weight were found for mTOR, phospho-mTOR, phospho-S6K, phospho-4E-BP1/2 and phospho-S6.


Gene_expression (/) of mTOR in bands
5) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0 Pain Relevance 0.04
One particular concern in the present series of experiments was the possible contribution of non-neuronal cells present in cutaneous tissues to maintaining the sensitivity of nociceptors through an mTOR mediated synthesis or release of trophic factors.
Gene_expression (synthesis) of mTOR in nociceptors associated with nociceptor
6) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.62 Pain Relevance 0.38
Furthermore, function-blocking anti-BDNF antibodies (Figure 6E) or rapamycin (Figure 6F) infused 2?
Gene_expression (antibodies) of rapamycin
7) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.24
We found that rapamycin and function blocking anti-BDNF antibodies infused into the dorsal hippocampus 15 min before or 2?
Gene_expression (found) of rapamycin in dorsal associated with hippocampus
8) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.19
The source of recovered FRAP is demonstrated by resectioning or recrushing the nerves.
Gene_expression (source) of FRAP in nerves
9) Confidence 0.55 Published 1985 Journal J. Comp. Neurol. Section Abstract Doc Link 3880359 Disease Relevance 0.09 Pain Relevance 0.28
In response to vascular injury, the expression of p-mTOR was increased after balloon injury due to proliferation of RAoSMCs.
Gene_expression (expression) of p-mTOR associated with injury and vasculitis
10) Confidence 0.53 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.50 Pain Relevance 0
Immunohistochemical staining of skin sections from glabrous and adjacent hairy skin of adult rat hindpaw showed that mTOR and phospho-mTOR were extensively expressed in subsets of primary afferent sensory fibers, identified from co-staining with PGP, a general marker for sensory afferents, as well as in non-neuronal cells of surrounding dermal tissue (Fig. 1A, B).
Gene_expression (expressed) of mTOR
11) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.15 Pain Relevance 0.38
Immunohistochemical staining of skin sections from glabrous and adjacent hairy skin of adult rat hindpaw showed that mTOR and phospho-mTOR were extensively expressed in subsets of primary afferent sensory fibers, identified from co-staining with PGP, a general marker for sensory afferents, as well as in non-neuronal cells of surrounding dermal tissue (Fig. 1A, B).
Gene_expression (expressed) of mTOR
12) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.15 Pain Relevance 0.37
This implies that a small number of C- fibers might have the capacity for mTOR mediated local protein synthesis but went undetected in our immunohistochemical or behavioural assays.
Gene_expression (synthesis) of mTOR
13) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.19 Pain Relevance 0.33
Cota et al. [14] reported that high leucine intakes affected to decrease food intake and body weight by stimulating the hypothalamic mammalian target of rapamycin (mTOR) signaling and there are relatively specific interactions among mTOR, leptin and insulin resistance.
Gene_expression (resistance) of mTOR in body associated with body weight and insulin resistance
14) Confidence 0.46 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.83 Pain Relevance 0
Activation of hypothalamic mTOR or increased expression of S6K in the mediobasal hypothalamus results in decreased feeding [12], [32]; therefore, Sirt1 down-regulating S6K signaling fits our model on the regulation of energy balance by hypothalamic Sirt1.
Gene_expression (expression) of mTOR in hypothalamus
15) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.06 Pain Relevance 0
Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord.
Gene_expression (produces) of FRAP in spinal cord associated with qutenza, spinal cord and substance p
16) Confidence 0.34 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 2423358 Disease Relevance 0 Pain Relevance 0.74
The IGF1-mTOR pathway demonstrated a very coherent level of regulation among the dietary groups of both genders, i.e. this pathway was significantly up-regulated in the same dietary groups (20% CR, 40% CR, HFG) in both genders.
Gene_expression (pathway) of mTOR
17) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0 Pain Relevance 0.05
The putative mTOR-mediated, protein synthesis-dependent trace induced when SKF-38393 was locally applied a day before conditioning did not supersede the need for other anisomycin-sensitive protein synthesis in the gerbil auditory cortex during postacquisition memory consolidation in the FM discrimination paradigm (Fig. 4D).
Gene_expression (synthesis) of mTOR in auditory cortex
18) Confidence 0.27 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0 Pain Relevance 0.30
Subpopulations of sensory neurons of rat dorsal root ganglia (DRG) can be identified by the immunocytochemical detection of lactoseries and globoseries carbohydrate differentiation antigens with monoclonal antibodies (MAbs) and by the histochemical demonstration of carbonic anhydrase (CA)- or fluoride-resistant acid phosphatase (FRAP) activities; therefore, these markers, and their coincident expression with neuropeptides, were studied in neurons of the rat small intestine.
Gene_expression (expression) of FRAP in dorsal root ganglia associated with neuropeptide
19) Confidence 0.22 Published 1988 Journal J. Comp. Neurol. Section Abstract Doc Link 3143749 Disease Relevance 0 Pain Relevance 0.11
At least five metabolites of everolimus are known, all with low mTOR inhibitory effect.43 Unlike temsirolimus, everolimus is not a prodrug of rapamycin.
Gene_expression (prodrug) of mTOR
20) Confidence 0.21 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.08 Pain Relevance 0

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