INT236167

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Lins) cellular_component (Lins) biological_process (Lins)
Anatomy Link Frequency
brain 1
heads 1
Lins (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 74.08 Quite High
imagery 63 14.24 Low Low
Peripheral nervous system 3 13.64 Low Low
Spinal cord 48 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
unmyelinated 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 100.00 Very High Very High Very High
Dislocations 3 82.80 Quite High
Death 3 40.44 Quite Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Spinal Cord Compression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The systematic use of GFP, while extremely useful for the analysis of single gene mutations or wildtype brain development, actually slows down mutant analysis because GFP expressing transgenic lines (Lichtman and Conchello, 2005; Shaner et al., 2005) have to be crossed into the mutant lines, which then have to be bred back to homozygosity.
Gene_expression (expressing) of lines in brain associated with targeted disruption
1) Confidence 0.06 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.10 Pain Relevance 0
For this study we used E18.5/P0 mouse embryonic spinal cords or heads of wild-type or several mutant lines with or without expression of GFP.
Gene_expression (expression) of lines in heads
2) Confidence 0.05 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0.08 Pain Relevance 0.07
Unfortunately, the conditional approach is not always feasible, since widespread expression of genes used for the currently available Cre lines to eliminate the LoxP flanked gene(s) of choice often gives rise to adverse effects in organs not targeted (Ohyama and Groves, 2004).
Gene_expression (expression) of lines
3) Confidence 0.04 Published 2007 Journal Immunological Investigations Section Body Doc Link PMC2430174 Disease Relevance 0 Pain Relevance 0

General Comments

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