INT236397

Context Info Confidence 0.33 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.91 Pain Relevance 0.24

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1) nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)

Anatomy Link Frequency endothelial cells 1 striatum 1 ECM 1 Flt1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 5 87.92 Intracerebroventricular 1 87.52 antagonist 12 79.20 Inflammatory response 6 76.72 Inflammation 9 66.40 metalloproteinase 5 26.60 agonist 1 20.64 Dopamine 1 20.32 imagery 9 14.64 corticosteroid 7 9.60

Disease Link Frequency Relevance Heat Targeted Disruption 1 94.64 Cancer 80 91.56 Diabetes Mellitus 55 89.20 Cv General 4 Under Development 2 87.92 Neuroblastoma 1 79.44 Brain Hemorrhage 2 77.68 Pituitary Cancer 8 77.00 Ganglion Cysts 2 76.96 INFLAMMATION 16 76.72 Gliosis 8 74.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, VEGF-A mutants that bind selectively to FLK-1 are able to induce mitogenesis and chemotaxis in endothelial cells, and vascular permeability and angiogenesis in vivo, whereas VEGF-A mutants that selectively bind to FLT-1 do not have the activities stated above (29,30).

FLT-1 Binding (bind) of in endothelial cells

1) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.55 Pain Relevance 0

It has been suggested that Flt1 may protect VEGF from proteolytic degradation by binding to it in the ECM [33].

Flt1 Binding (binding) of in ECM

2) Confidence 0.33 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.45 Pain Relevance 0

In this case Cyclo-VEGI binding to VEGFR-1 in activated microglia could inhibit cellular reactivity and VEGF production leading to a reduced vascular permeability for fibrinogen infiltration into striatum.

VEGFR-1 Binding (binding) of in striatum

3) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.28 Pain Relevance 0.11

VEGF-A binds both VEGFR-1 and VEGFR-2, while PlGF and VEGF-B interact only with VEGFR-1.

VEGFR-1 Binding (binds) of

4) Confidence 0.18 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.37 Pain Relevance 0

VEGF is one of the signaling molecules that binds to its receptors on cell membrane, VEGFR1 and VEGFR2, initiating signaling pathways through Akt activation.

VEGFR1 Binding (binds) of

5) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.26 Pain Relevance 0.13

General Comments

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