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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.91
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
endothelial cells 1
striatum 1
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 87.92 High High
Intracerebroventricular 1 87.52 High High
antagonist 12 79.20 Quite High
Inflammatory response 6 76.72 Quite High
Inflammation 9 66.40 Quite High
metalloproteinase 5 26.60 Quite Low
agonist 1 20.64 Low Low
Dopamine 1 20.32 Low Low
imagery 9 14.64 Low Low
corticosteroid 7 9.60 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 94.64 High High
Cancer 80 91.56 High High
Diabetes Mellitus 55 89.20 High High
Cv General 4 Under Development 2 87.92 High High
Neuroblastoma 1 79.44 Quite High
Brain Hemorrhage 2 77.68 Quite High
Pituitary Cancer 8 77.00 Quite High
Ganglion Cysts 2 76.96 Quite High
INFLAMMATION 16 76.72 Quite High
Gliosis 8 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, VEGF-A mutants that bind selectively to FLK-1 are able to induce mitogenesis and chemotaxis in endothelial cells, and vascular permeability and angiogenesis in vivo, whereas VEGF-A mutants that selectively bind to FLT-1 do not have the activities stated above (29,30).
FLT-1 Binding (bind) of in endothelial cells
1) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.55 Pain Relevance 0
It has been suggested that Flt1 may protect VEGF from proteolytic degradation by binding to it in the ECM [33].
Flt1 Binding (binding) of in ECM
2) Confidence 0.33 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.45 Pain Relevance 0
In this case Cyclo-VEGI binding to VEGFR-1 in activated microglia could inhibit cellular reactivity and VEGF production leading to a reduced vascular permeability for fibrinogen infiltration into striatum.
VEGFR-1 Binding (binding) of in striatum
3) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.28 Pain Relevance 0.11
VEGF-A binds both VEGFR-1 and VEGFR-2, while PlGF and VEGF-B interact only with VEGFR-1.
VEGFR-1 Binding (binds) of
4) Confidence 0.18 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.37 Pain Relevance 0
VEGF is one of the signaling molecules that binds to its receptors on cell membrane, VEGFR1 and VEGFR2, initiating signaling pathways through Akt activation.
VEGFR1 Binding (binds) of
5) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.26 Pain Relevance 0.13

General Comments

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