INT236403

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Flt1, VEGFA) cell differentiation (Flt1) endosome (Flt1)
Golgi apparatus (Flt1) extracellular space (VEGFA) growth (VEGFA)
Anatomy Link Frequency
striatum 3
Flt1 (Rattus norvegicus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 6 82.88 Quite High
antagonist 12 79.20 Quite High
Inflammation 9 66.40 Quite High
Inflammatory mediators 1 7.12 Low Low
Glutamate 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 82.88 Quite High
Gliosis 8 74.96 Quite High
Congenital Anomalies 3 71.12 Quite High
Injury 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case Cyclo-VEGI binding to VEGFR-1 in activated microglia could inhibit cellular reactivity and VEGF production leading to a reduced vascular permeability for fibrinogen infiltration into striatum.
VEGFR-1 Binding (binding) of in striatum Negative_regulation (inhibit) of Gene_expression (production) of VEGF in striatum
1) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.30 Pain Relevance 0.11

General Comments

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