INT236487

Context Info Confidence 0.08 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.77 Pain Relevance 1.45

molecular_function (Grina) cellular_component (Grina) biological_process (Grina)

Anatomy Link Frequency forebrain 2 Grina (Mus musculus)

Pain Link Frequency Relevance Heat nMDA receptor 8 100.00 IPN 2 99.92 Pain 152 99.24 Neuropeptide 1 98.50 Cancer pain 17 97.16 long-term potentiation 1 80.80 c fibre 15 71.04 Acute pain 1 61.28 Neuropathic pain 4 55.68 Inflammation 10 54.84

Disease Link Frequency Relevance Heat Inflammatory Pain 2 99.92 Pain 160 99.24 Bone Cancer 41 99.00 Targeted Disruption 7 85.88 Sprains And Strains 5 78.72 Nociception 14 75.96 Disease 7 68.76 Cancer 75 68.52 Neuropathic Pain 13 55.68 INFLAMMATION 13 54.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In bone cancer models pain-related behaviors are accompanied by increased expression of NR2B, an NMDA receptor subunit.

Positive_regulation (increased) of Gene_expression (expression) of NMDA receptor subunit associated with pain, nmda receptor and bone cancer

1) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.61 Pain Relevance 0.60

Examples of transgenics that have generated insights into pain pathways are numerous, and include reports of modulation of pain behaviour by the overexpression of the neuropeptide galanin [28], and the enhancement of inflammatory pain by overexpression of the NMDA receptor subunit N2RB in the forebrain [29].

Positive_regulation (overexpression) of Gene_expression (overexpression) of NMDA receptor subunit in forebrain associated with pain, nmda receptor, ipn and neuropeptide

2) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.16 Pain Relevance 0.85

General Comments

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