INT23657

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 64
Total Number 65
Disease Relevance 39.76
Pain Relevance 16.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
neuronal 4
neurons 4
skin 3
Plasma 2
brain 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 238 100.00 Very High Very High Very High
halothane 6 99.98 Very High Very High Very High
Adelta 2 99.80 Very High Very High Very High
Pain 20 99.40 Very High Very High Very High
isoflurane 6 99.38 Very High Very High Very High
cINOD 82 99.32 Very High Very High Very High
allodynia 4 99.28 Very High Very High Very High
cytokine 60 99.14 Very High Very High Very High
Hyperesthesia 1 98.00 Very High Very High Very High
c fibre 1 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 887 100.00 Very High Very High Very High
Alzheimer's Dementia 246 100.00 Very High Very High Very High
Targeted Disruption 68 100.00 Very High Very High Very High
Toxicity 41 99.96 Very High Very High Very High
Neurodegenerative Disease 111 99.92 Very High Very High Very High
Cognitive Disorder 132 99.84 Very High Very High Very High
Cancer 110 99.80 Very High Very High Very High
Disorder Of Lipid Metabolism 4 99.72 Very High Very High Very High
Pain 26 99.40 Very High Very High Very High
Immunization 13 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that isoflurane-induced Abeta oligomerization and apoptosis may contribute to the risk of postoperative cognitive dysfunction and provide a potential pathogenic link between delirium and dementia.


Positive_regulation (induced) of Abeta
1) Confidence 0.70 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 17234824 Disease Relevance 0.06 Pain Relevance 0
The role of these fibers in clinical pain syndromes can be evaluated by applications of electrical stimuli that preferentially activate Abeta axons.
Positive_regulation (activate) of Abeta associated with pain, syndrome and abeta
2) Confidence 0.70 Published 2003 Journal J Pain Symptom Manage Section Abstract Doc Link 12565190 Disease Relevance 0.41 Pain Relevance 0.45
It is a heterogeneous disease involving a number of genetic components, risk factors and other poorly defined elements that all impact on the accumulation of beta-amyloid peptide (Abeta).
Positive_regulation (accumulation) of Abeta associated with alzheimer's dementia, disease and abeta
3) Confidence 0.69 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 0.94 Pain Relevance 0.19
These and other observations endorse the notion that therapeutic strategies targeting the inhibition of Abeta accumulation by the use of protease inhibitors,immunization or other strategies, may provide disease-altering interventions to the development and progression of AD.
Positive_regulation (accumulation) of Abeta associated with immunization, disease and abeta
4) Confidence 0.69 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 1.44 Pain Relevance 0.34
It is a heterogeneous disease involving a number of genetic components, risk factors and other poorly defined elements that all impact on the accumulation of beta-amyloid peptide (Abeta).
Positive_regulation (accumulation) of beta-amyloid peptide associated with alzheimer's dementia, disease and abeta
5) Confidence 0.69 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 0.94 Pain Relevance 0.19
In addition, OSBP1 overexpression was unable to further alter the concomitant increase in APP-CTF?
Positive_regulation (increase) of APP
6) Confidence 0.68 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
GSMs are attractive targets for Alzheimer's disease, in contrast to 'inverse GSMs,' such as fenofibrate, which selectively increase the level of Abeta(1-42).
Positive_regulation (increase) of Abeta associated with disease and abeta
7) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.54 Pain Relevance 0.63
While many issues remain controversial, recent evidence attributing Abeta accumulation to cognitive decline in humans, coupled to the demonstrated improvement of cognitive function following Abeta immunization in pre-clinical models, strongly supports the "amyloid hypothesis" and a central role for Abeta; in the pathophysiology and etiology of AD.
Positive_regulation (accumulation) of Abeta associated with cognitive disorder, alzheimer's dementia, immunization, disease and abeta
8) Confidence 0.60 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 1.28 Pain Relevance 0.27
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with reduced risk for Alzheimer's disease (AD) and selected NSAIDs racemates suppress beta-amyloid (Abeta) accumulation in vivo and Abeta42 production in vitro.
Positive_regulation (accumulation) of Abeta associated with inflammation, alzheimer's dementia, cinod, disease and abeta
9) Confidence 0.51 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12421374 Disease Relevance 0.58 Pain Relevance 0.51
This neuronal loss is accompanied by punctate deposits of material that are immunoreactive for amyloid precursor protein, beta-amyloid peptide (Abeta), and apolipoprotein E.
Positive_regulation (immunoreactive) of Abeta in neuronal associated with alzheimer's dementia, disorder of lipid metabolism and abeta
10) Confidence 0.50 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 1.06 Pain Relevance 0.38
This neuronal loss is accompanied by punctate deposits of material that are immunoreactive for amyloid precursor protein, beta-amyloid peptide (Abeta), and apolipoprotein E.
Positive_regulation (immunoreactive) of beta-amyloid peptide in neuronal associated with alzheimer's dementia, disorder of lipid metabolism and abeta
11) Confidence 0.50 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 1.05 Pain Relevance 0.38
This neuronal loss is accompanied by punctate deposits of material that are immunoreactive for amyloid precursor protein, beta-amyloid peptide (Abeta), and apolipoprotein E.
Positive_regulation (immunoreactive) of amyloid precursor protein in neuronal associated with alzheimer's dementia, disorder of lipid metabolism and abeta
12) Confidence 0.50 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 1.05 Pain Relevance 0.38
Based on this model, we systematically demonstrated that several classes of organic compounds (e.g., wine-related polyphenols, non-steroidal anti-inflammatory drugs) not only inhibit the formation of Abeta amyloid fibrils from Abeta and their extension, but also destabilize Abeta amyloid fibrils dose-dependently in vitro.
Positive_regulation (destabilize) of Abeta associated with inflammation, alzheimer's dementia, cinod and abeta
13) Confidence 0.50 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20371993 Disease Relevance 0.59 Pain Relevance 0.35
While many issues remain controversial, recent evidence attributing Abeta accumulation to cognitive decline in humans, coupled to the demonstrated improvement of cognitive function following Abeta immunization in pre-clinical models, strongly supports the "amyloid hypothesis" and a central role for Abeta; in the pathophysiology and etiology of AD.
Positive_regulation (supports) of Abeta associated with cognitive disorder, alzheimer's dementia, immunization, disease and abeta
14) Confidence 0.50 Published 2002 Journal Curr Top Med Chem Section Abstract Doc Link 11966458 Disease Relevance 1.44 Pain Relevance 0.34
42 into the surrounding milieu, which may stimulate the production of amyloidogenic fragments of APP, amplify the levels of intracellular A?
Positive_regulation (fragments) of APP
15) Confidence 0.50 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.50 Pain Relevance 0
Addition of 25OH, which induces translocation of OSBP1 from the ER/cytoplasm to the Golgi, caused APP-Notch2 dimers to translocate from the Golgi to the ER.
Positive_regulation (caused) of APP
16) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
The largest Abeta fibres can be activated up to a maximum depth of about 0.25 mm in the DCs.
Positive_regulation (activated) of Abeta associated with abeta
17) Confidence 0.49 Published 2002 Journal Brain Section Abstract Doc Link 11960902 Disease Relevance 0.10 Pain Relevance 0.59
The final step in the generation of Abeta from the amyloid precursor protein is catalyzed by the multiprotein complex gamma-secretase, which constitutes a prime drug target for prevention and therapy of the disease.
Positive_regulation (generation) of Abeta associated with alzheimer's dementia, disease and abeta
18) Confidence 0.49 Published 2006 Journal Neurodegener Dis Section Abstract Doc Link 17047371 Disease Relevance 0.76 Pain Relevance 0.21
Genetic evidence suggests that generation of amyloid beta peptide is the pivotal step in the pathophysiology of Alzheimer's disease (AD).
Positive_regulation (generation) of amyloid beta peptide associated with alzheimer's dementia and disease
19) Confidence 0.48 Published 2002 Journal Lancet Neurol Section Abstract Doc Link 12849425 Disease Relevance 0.94 Pain Relevance 0.33
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Positive_regulation (activation) of APP associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
20) Confidence 0.47 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.85 Pain Relevance 0.36

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