INT236693

Context Info Confidence 0.15 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.06 Pain Relevance 0.14

cell morphogenesis (Bcl6) nucleus (Bcl6) intracellular (Bcl6) DNA binding (Bcl6)

Anatomy Link Frequency B-cell 4 plasma cells 2 Bcl6 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 12 92.28 cytokine 4 65.84 agonist 9 58.48 cINOD 8 5.00 dexamethasone 4 5.00 Potency 3 5.00 COX2 2 5.00 alcohol 1 5.00 cva 1 5.00 aspirin 1 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 25 100.00 Otitis Media With Effusion 41 99.68 INFLAMMATION 14 92.28 Cancer 105 86.16 Leukemia 9 83.92 Skin Cancer 4 82.12 Infection 11 81.68 Breast Cancer 8 80.68 Disease 39 74.28 Acute Promyelocytic Leukemia 1 73.16

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BCL-6 was first discovered as a gene translocated in a type of non-Hodgkin's lymphoma, but it has not been found in terminally differentiated plasma cells.28,29 We found that BCL-6 expression was significantly lower in the OME group, and that it was expressed primarily in the germinal centers.

Positive_regulation (lower) of Gene_expression (expression) of BCL-6 in plasma cells associated with lymphatic system cancer and otitis media with effusion

1) Confidence 0.15 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.58 Pain Relevance 0.05

corepressors, such as B-cell lymphoma 6 (BCL-6), silencing mediator for

Positive_regulation (as) of Gene_expression (corepressors) of BCL-6 in B-cell associated with lymphatic system cancer

2) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.39 Pain Relevance 0.10

BCL-6 is overexpressed in 40% of diffuse large B-cell lymphomas (Pasqualucci et al. 2003).

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of BCL-6 in B-cell associated with lymphatic system cancer

3) Confidence 0.05 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.08 Pain Relevance 0

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