INT236826

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.10

plasma membrane (DCSTAMP)

Anatomy Link Frequency chondrocytes 2 DCSTAMP (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 2 100.00 Inflammation 22 94.68 Bioavailability 4 48.24 Arthritis 9 5.00 cytokine 4 5.00 Inflammatory stimuli 4 5.00 cINOD 3 5.00 Inflammatory mediators 2 5.00 Osteoarthritis 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 30 94.68 Arthritis 11 5.00 Disease 5 5.00 Chronic Disease 5 5.00 Prostate Cancer 2 5.00 Peptic Ulcer 2 5.00 Apoptosis 2 5.00 Cancer 2 5.00 Osteoarthritis 2 5.00 Ulcers 1 5.00

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro Several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo.

Negative_regulation (inhibit) of Gene_expression (production) of IL-1beta-induced in chondrocytes associated with inflammation and cox2

1) Confidence 0.02 Published 2008 Journal J Inflamm (Lond) Section Title Doc Link PMC2438359 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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