INT237104

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.69
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
alveolar macrophages 4
HMI (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 50 100.00 Very High Very High Very High
chemokine 2 12.48 Low Low
cytokine 8 12.00 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 100.00 Very High Very High Very High
Invasive Pulmonary Aspergillosis 50 100.00 Very High Very High Very High
Disease 13 99.62 Very High Very High Very High
Nicotine Addiction 2 98.94 Very High Very High Very High
Pulmonary Disease 22 98.70 Very High Very High Very High
Bites And Stings 6 68.72 Quite High
Adhesions 6 66.00 Quite High
Toxicity 40 50.00 Quite Low
Aspergillus Infection 9 50.00 Quite Low
Stress 11 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Learning impairment is specifically caused by exposure to IPA
Positive_regulation (caused) of Gene_expression (exposure) of IPA
1) Confidence 0.29 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0.07 Pain Relevance 0
There is also a reduction in total HDAC activity in peripheral lung, bronchial biopsy specimens, and alveolar macrophages from COPD patients, and this is correlated with disease severity and with increased gene expression of IL-8 (Ito et al., 2005).
Positive_regulation (increased) of Gene_expression (expression) of Ito in alveolar macrophages associated with pulmonary disease and disease
2) Confidence 0.16 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.14 Pain Relevance 0.26
HDAC activity is reduced in alveolar macrophages of cigarette smokers compared to nonsmokers, and this is correlated with increased expression of inflammatory genes in these cells (Ito et al., 2001).
Positive_regulation (increased) of Gene_expression (expression) of Ito in alveolar macrophages associated with nicotine addiction and inflammation
3) Confidence 0.11 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.24 Pain Relevance 0.27
The rigorous quality control steps incorporated in our qPCR assay significantly enhance the reliability of the results and therefore may increase our understanding of the true potential of qPCR for the diagnosis of IPA.


Positive_regulation (potential) of Gene_expression (diagnosis) of IPA associated with invasive pulmonary aspergillosis
4) Confidence 0.08 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2440748 Disease Relevance 0.24 Pain Relevance 0

General Comments

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