INT237256

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.64
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rhbdl1)
Anatomy Link Frequency
RRP 3
juvenile 1
synapses 1
Rhbdl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 133 99.84 Very High Very High Very High
Action potential 118 99.36 Very High Very High Very High
depression 84 91.60 High High
noradrenaline 9 71.76 Quite High
Dorsal horn 3 60.68 Quite High
Glutamate receptor 9 50.00 Quite Low
antagonist 10 29.16 Quite Low
Hippocampus 1 12.72 Low Low
agonist 27 5.00 Very Low Very Low Very Low
tetrodotoxin 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papilloma 114 100.00 Very High Very High Very High
Malignant Neoplastic Disease 22 99.72 Very High Very High Very High
Papillomavirus Infection 30 98.16 Very High Very High Very High
Depression 84 91.60 High High
Nicotine Addiction 8 90.72 High High
Cleidocranial Dysplasia 60 87.24 High High
Carcinoma 8 87.08 High High
Adenocarcinoma 6 85.12 High High
Retinitis 8 64.40 Quite High
Cytomegalovirus Infection 10 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given this number of vesicles in the RRP, if each has a Pv of 0.1 this indicates that sparse stimulation with single APs causes hippocampal synapses from rat neurons in primary culture to release, on average, 1 vesicle every 3 APs in standard conditions, (Pr?
Positive_regulation (Given) of RRP in synapses associated with action potential
1) Confidence 0.47 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.20 Pain Relevance 0.27
Because of the increasing use of cidofovir for RRP, there is a demand for a qualitative review of the side-effects of this drug.
Positive_regulation (increasing) of RRP associated with papilloma
2) Confidence 0.46 Published 2008 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2441494 Disease Relevance 1.67 Pain Relevance 0
Spontaneous malignant degeneration occurs in both juvenile-onset RRP and adult-onset RRP and carries a dismal prognosis [29].
Positive_regulation (occurs) of RRP in juvenile associated with malignant neoplastic disease and papilloma
3) Confidence 0.40 Published 2008 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2441494 Disease Relevance 2.07 Pain Relevance 0
A number of studies have suggested that the size of the readily releasable pool of vesicles (RRP) correlates with the probability of release, such that an increased probability of release should also increase the size of the RRP (Rosenmund and Stevens, 1996; Dobrunz and Stevens, 1997; Goussakov et al., 2000).
Positive_regulation (increase) of RRP in RRP
4) Confidence 0.10 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.08 Pain Relevance 0.11
For example, recent studies of group III mGluR in the medial nucleus of the trapezoid body (Billups et al., 2005) strongly suggest that the main action of mGluRs is to depress release probability (P), but this is matched by an increase in the size of the RRP of glutamate vesicles (N).
Positive_regulation (increase) of RRP in RRP associated with glutamate
5) Confidence 0.09 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.24 Pain Relevance 0.17
It is also clear that the cAMP signaling machinery has the ability to mediate enhancement of the size of the RRP.
Positive_regulation (enhancement) of RRP in RRP
6) Confidence 0.07 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.39 Pain Relevance 0.23

General Comments

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