INT237340
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Occasional small foci of inflammatory infiltrates were observed in AAV-transduced mKO muscles, often nearby myofibers expressing high levels of myotubularin (Fig. 3C). | |||||||||||||||
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The same phenotype is observed when the Mtm1 gene is inactivated only in skeletal muscle, indicating that myotubularin exerts a muscle autonomous function (12). | |||||||||||||||
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Myotubularin is ubiquitously expressed in mouse tissues, being more abundant in striated muscles than in sciatic nerve and brain, and increases during the first postnatal week in skeletal muscle (Supplementary Material, Fig. | |||||||||||||||
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We tested whether AAV-mediated myotubularin replacement could be beneficial at the functional level because muscle weakness is the constant and life threatening sign of the disease. | |||||||||||||||
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We found that, in both conditions, myotubularin is distributed in the cytosolic S3 fraction, containing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and in the membrane P3 fraction, containing caveolin 3 (which is associated with sarcolemmal caveolae) (Fig. 5D). | |||||||||||||||
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General Comments
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