INT237347

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.03

cell differentiation (Bin1) nucleus (Bin1) cytoplasm (Bin1)

Bin1 (Mus musculus)

Pain Link Frequency Relevance Heat sodium channel 1 52.16 Inflammation 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 Sciatic nerve 1 5.00

Disease Link Frequency Relevance Heat Congenital Structural Myopathies 17 100.00 Frailty 2 98.08 Muscle Weakness 4 97.60 Paralysis 1 59.92 Demyelinating Disease 2 8.88 Cytomegalovirus Infection 13 5.00 Disease 5 5.00 Muscle Disease 5 5.00 Charcot Marie Tooth Disease 4 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, mutations in the amphyphisin 2/Bin1 gene in patients with an autosomal recessive form of CNM were shown to alter its membrane tubulation properties and interaction with dynamin 2 (6).

Bin1 Binding (interaction) of associated with congenital structural myopathies

1) Confidence 0.36 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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