INT237353

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.04

plasma membrane (MTM1) cytoplasm (MTM1)

Anatomy Link Frequency muscle 1 MTM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 88.04 ketamine 1 5.00 anesthesia 1 5.00 sodium channel 1 5.00 Sciatic nerve 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 2 88.04 Muscle Weakness 4 84.32 Disease 5 79.12 Cytomegalovirus Infection 13 75.20 Congenital Structural Myopathies 17 50.00 Muscle Disease 5 5.00 Charcot Marie Tooth Disease 4 5.00 Demyelinating Disease 2 5.00 Death 2 5.00 Anaerobic Bacterial Infections 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Altogether, our results demonstrate that a single intramuscular injection of a rAAV vector carrying a Mtm1 cDNA is sufficient to ameliorate the pathology of an already affected XLMTM muscle.

Regulation (affected) of XLMTM in muscle

1) Confidence 0.04 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.39 Pain Relevance 0.04

General Comments

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