INT237703

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rheumatism 1 99.92 Very High Very High Very High
Arthritis 6 99.48 Very High Very High Very High
Inflammation 28 98.60 Very High Very High Very High
rheumatoid arthritis 10 90.56 High High
cytokine 3 87.96 High High
Inflammatory mediators 1 87.92 High High
Inflammatory stimuli 2 79.28 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatic Diseases 1 99.92 Very High Very High Very High
Arthritis 6 99.48 Very High Very High Very High
INFLAMMATION 33 98.96 Very High Very High Very High
Rheumatoid Arthritis 10 90.56 High High
Bacterial Respiratory Disease 12 51.40 Quite High
Urinary Tract Infection 96 5.00 Very Low Very Low Very Low
Pyelonephritis 90 5.00 Very Low Very Low Very Low
Infection 81 5.00 Very Low Very Low Very Low
Sprains And Strains 51 5.00 Very Low Very Low Very Low
Disease 49 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that ceramide triggers TRAM phosphorylation more efficiently than LPS+sCD14.
Phosphorylation (phosphorylation) of LPS
1) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0
CREB phosphorylation in r-ceramide-activated cells was confirmed by confocal microscopy (Figure 3D, E, p<0.001 compared to control), but was not detected in LPS-stimulated cells.
Phosphorylation (phosphorylation) of LPS
2) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.05 Pain Relevance 0.04
LPS and SNP rapidly phosphorylates ERK, p38 and JNK, which lead to NF-?
Phosphorylation (phosphorylates) of LPS
3) Confidence 0.04 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.85 Pain Relevance 0.43
LPS+sCD14 triggered weaker TRAM phosphorylation, as shown by confocal microscopy (p<0.001 compared to r-ceramide) and by Western blot.
Phosphorylation (phosphorylation) of LPS
4) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0

General Comments

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