INT237709

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.09
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
fibroblasts 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 18 99.58 Very High Very High Very High
dexamethasone 11 97.36 Very High Very High Very High
Osteoarthritis 63 89.36 High High
Inflammation 99 84.16 Quite High
Nicotine 96 81.76 Quite High
cytokine 16 66.80 Quite High
agonist 37 62.76 Quite High
b2 receptor 30 62.20 Quite High
Kinase C inhibitor 1 60.64 Quite High
Inflammatory response 4 30.92 Quite Low
Disease Link Frequency Relevance Heat
Stress 106 99.04 Very High Very High Very High
Apoptosis 29 97.44 Very High Very High Very High
Osteoarthritis 66 89.36 High High
Disease 204 84.16 Quite High
INFLAMMATION 109 84.16 Quite High
Asthma 15 48.08 Quite Low
Adhesions 1 29.20 Quite Low
Down Syndrome 16 5.00 Very Low Very Low Very Low
Obesity 15 5.00 Very Low Very Low Very Low
Nicotine Addiction 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of JNK inhibition, the response of normal control fibroblasts after oxidative stress amounted to at most 30% apoptotic nuclei at both 250 µM (Figure 16A) and 500 µM (Figure 14) H2O2 by 10 hr after oxidative stress.
Negative_regulation (absence) of Negative_regulation (inhibition) of JNK in fibroblasts associated with stress and apoptosis
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.70 Pain Relevance 0
In addition to the effect of JNK inhibitor, inhibitors of other MAP-kinases, that is, SB220025 (p38 inhibitor; 0.5 ?
Negative_regulation (effect) of Negative_regulation (inhibitor) of JNK
2) Confidence 0.23 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.23 Pain Relevance 0.18
Secondly, we found that pre-incubation of cells with the novel PAR2 antagonist K-14585 was able to reverse the inhibition of JNK mediated by the human PAR2 activating peptide SLIGKV-OH (Panel B).
Negative_regulation (reverse) of Negative_regulation (inhibition) of JNK associated with antagonist
3) Confidence 0.22 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.08
In the present study we demonstrated complete reversal of PAR2 mediated JNK inhibition.
Negative_regulation (reversal) of Negative_regulation (inhibition) of JNK
4) Confidence 0.21 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
They include both inhibition of the upstream negative regulator of JNK and p38 MAPKs called MAP kinase phosphatase-1 [48] and post-transcriptional/translational regulation of gene expressions [42,49].
Negative_regulation (inhibition) of Negative_regulation (regulator) of JNK
5) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.16 Pain Relevance 0.46
B activation, we explored JNK specific inhibitor SP600125 (10–50 ?
Negative_regulation (explored) of Negative_regulation (inhibitor) of JNK
6) Confidence 0.11 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0

General Comments

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