INT23775

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 16.75
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
Neuron 6
brain 2
plasma 1
smooth muscle 1
Langerhans cells 1
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 99.74 Very High Very High Very High
Inflammation 53 99.12 Very High Very High Very High
Central nervous system 18 98.72 Very High Very High Very High
analgesia 4 96.32 Very High Very High Very High
Enkephalin 2 95.52 Very High Very High Very High
imagery 14 92.24 High High
Neuritis 2 92.12 High High
ischemia 1 91.96 High High
headache 5 90.44 High High
antidepressant 45 89.96 High High
Disease Link Frequency Relevance Heat
Depression 57 100.00 Very High Very High Very High
Sepsis 50 100.00 Very High Very High Very High
Encephalopathy 38 100.00 Very High Very High Very High
Stress 38 100.00 Very High Very High Very High
Neuromyelitis Optica 28 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 2 100.00 Very High Very High Very High
Langerhans-cell Histiocytosis 6 99.14 Very High Very High Very High
INFLAMMATION 63 99.12 Very High Very High Very High
Obesity 152 98.76 Very High Very High Very High
Cancer 44 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When this blood is retransfused either directly by cardiotomy suction or later in the course by autotransfusion during the postoperative care, the systemic levels of S100B are affected.
Regulation (affected) of S100B in blood
1) Confidence 0.62 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.06 Pain Relevance 0
The aim of the present study was to investigate the value of S-100 and neuron specific enolase (NSE) in reflecting postoperative cognitive deficit (POCD) after general surgical procedures.
Spec (investigate) Regulation (value) of S-100 in neuron associated with cognitive disorder
2) Confidence 0.60 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 11952437 Disease Relevance 0.45 Pain Relevance 0.12
S-100beta protein and Neuron-Specific Enolase levels were unaffected by anesthetic technique.


Neg (unaffected) Regulation (unaffected) of S-100beta in Neuron
3) Confidence 0.60 Published 2005 Journal Can J Anaesth Section Body Doc Link 15684252 Disease Relevance 0 Pain Relevance 0
Besides, S100B positive-astrocytes located in the ipsilateral side showed an increase in their arborization, but not in the level of expression of the S100B protein.
Neg (not) Regulation (level) of S100B in astrocytes
4) Confidence 0.45 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20043976 Disease Relevance 0.39 Pain Relevance 0.22
Do extracranial sources contribute to the clinical test for serum S100B?
Regulation (contribute) of S100B
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.18 Pain Relevance 0.03
Immunohistochemical staining is typically positive for S-100, Vimentin and Neuron-specific enolase.
Regulation (positive) of S-100 in Neuron
6) Confidence 0.44 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2645401 Disease Relevance 1.24 Pain Relevance 0.07
Immunoreactivity for CEA, S-100 and CLA was not present in any tumors.
Regulation (Immunoreactivity) of S-100 associated with cancer
7) Confidence 0.44 Published 1986 Journal J. Cutan. Pathol. Section Abstract Doc Link 2430002 Disease Relevance 1.02 Pain Relevance 0.20
Thus, the diagnostic value of S100B and its negative predictive value in neurological diseases in intact subjects (without traumatic brain or bodily injury from accident or surgery) are not compromised in the clinical setting.



Regulation (value) of S100B in brain associated with neurological disease and injury
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.56 Pain Relevance 0
These antibodies were selected because they target different regions of the S100B protein (see legend of Figure 1).
Regulation (target) of S100B protein
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0 Pain Relevance 0
The objective of this study was to characterize the tissue specificity of S100B and assess how extracranial sources of S100B affect serum levels.
Regulation (specificity) of S100B
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.41 Pain Relevance 0.04
Our attempt to control the increased levels of S100B caused by contamination from the surgical field did not yield different results.
Regulation (control) of S100B
11) Confidence 0.27 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC544890 Disease Relevance 0.16 Pain Relevance 0
Light microscopy showed LCH, and immunohistochemical studies revealed S-100 and CD1a immunoreactivity in the Langerhans cells.
Regulation (immunoreactivity) of S-100 in Langerhans cells associated with langerhans-cell histiocytosis
12) Confidence 0.26 Published 2004 Journal Brain Tumor Pathol Section Abstract Doc Link 15700840 Disease Relevance 0.90 Pain Relevance 0.14
The effect of apolipoprotein E genotype on neuron specific enolase and S-100beta levels after cardiac surgery.
Regulation (effect) of S-100beta in neuron associated with disorder of lipid metabolism
13) Confidence 0.26 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15502024 Disease Relevance 0.29 Pain Relevance 0.16
These results corroborate a differential regulation of IgG-NMO autoantibodies on the S100beta glial marker and on the disability present in rNMO patients.
Regulation (regulation) of S100beta associated with neuromyelitis optica
14) Confidence 0.26 Published 2010 Journal Neuroimmunomodulation Section Abstract Doc Link 20134196 Disease Relevance 1.40 Pain Relevance 0.16
Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica.
Regulation (regulation) of S100Beta associated with neuromyelitis optica
15) Confidence 0.26 Published 2010 Journal Neuroimmunomodulation Section Title Doc Link 20134196 Disease Relevance 1.50 Pain Relevance 0.23
Changes in S-100beta protein and Neuron-Specific Enolase levels were also documented.
Regulation (Changes) of S-100beta in Neuron
16) Confidence 0.26 Published 2005 Journal Can J Anaesth Section Body Doc Link 15684252 Disease Relevance 0 Pain Relevance 0
Statistical analysis of the mean values of S100beta levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls (P = .001).
Regulation (values) of S100beta
17) Confidence 0.26 Published 2005 Journal Headache Section Body Doc Link 16324163 Disease Relevance 0.08 Pain Relevance 0
The results of previous studies comparing the serum S100B levels of depressive patients and normal controls showed that depressive patients had higher serum S100B levels than normal controls.17,19,20,35 However, there was no difference in the serum S100B levels of depressive patients and normal controls observed in the present study.
Regulation (controls) of S100B associated with depression
18) Confidence 0.24 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.57 Pain Relevance 0.14
Recently Schulpis et al [13] investigated the effect of the mode of labour and delivery on the protein S100B serum concentrations in mothers and their newborns and demonstrated an increase of S100B serum levels in the mothers who delivered with prolonged labour for natural way.
Spec (investigated) Regulation (effect) of protein S100B
19) Confidence 0.24 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.15 Pain Relevance 0.03
We therefore wished to investigate the S100B values in serum of patients or controls across, to our knowledge, the broadest published population of subjects.
Spec (investigate) Regulation (values) of S100B
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.36 Pain Relevance 0.03

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