INT238215

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.63
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STAT3, Bmx) signal transduction (STAT3, Bmx) nucleoplasm (STAT3)
DNA binding (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
Anatomy Link Frequency
myocardium 3
bands 1
STAT3 (Homo sapiens)
Bmx (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 7 79.84 Quite High
cytokine 28 44.60 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Immobilon 7 5.00 Very Low Very Low Very Low
Thoracotomy 7 5.00 Very Low Very Low Very Low
Acupuncture 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 56 98.70 Very High Very High Very High
Hyperplasia 7 86.00 High High
Coronary Heart Disease 49 82.00 Quite High
Apoptosis 14 69.12 Quite High
Hypertrophy 42 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 14 5.00 Very Low Very Low Very Low
Fibrosis 7 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Reperfusion Injury 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, to demonstrate that PO induces BMX interaction with STAT3 in vivo and possibly serves as an upstream kinase, we gently solubilized the MSK fractions from control and PO felines with mRIPA buffer.
STAT3 Binding (interaction) of BMX
1) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
When STAT3 immunoprecipitates were analyzed, BMX was found to be complexed with STAT3 only in PO RV samples.
STAT3 Binding (complexed) of BMX
2) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Although our studies3-5 indicate that most focal adhesion proteins are found in the CSK fraction, it is not clear whether BMX and STAT3, which are complexed in the MSK fraction, are part of the focal adhesion or represent an independent localization in the cell.
STAT3 Binding (complexed) of BMX associated with adhesions
3) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.20 Pain Relevance 0.04
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
STAT3 Binding (complex) of BMX in myocardium
4) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Since both STAT3 and BMX exhibit similar redistribution and phosphorylation, these data and our in vivo observations showing a complex formation between BMX and STAT3 in PO myocardium strongly indicate that integrin-mediated BMX activation might serve as an upstream kinase for STAT3 activation in hypertrophying myocardium.
STAT3 Binding (formation) of BMX in myocardium
5) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.20 Pain Relevance 0.04
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
STAT3 Binding (complex) of BMX in myocardium
6) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Finally, the bands seen in the Western blot for BMX and STAT3 could not be due to STAT3 antibody cross reaction, since normally loaded LV sample does not show such bands corresponding to BMX and STAT3.


STAT3 Binding (due) of BMX in bands
7) Confidence 0.10 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.23 Pain Relevance 0

General Comments

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