INT238333

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.14

extracellular region (PDGFA, ADAMTS1) peptidase activity (ADAMTS1) extracellular space (PDGFA) embryo development (PDGFA) cell-cell signaling (PDGFA)

PDGFA (Homo sapiens) ADAMTS1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 11 95.36 Pain 14 90.44 metalloproteinase 8 5.00 Mechanotransduction 1 5.00

Disease Link Frequency Relevance Heat Tendinopathy 10 5.00 Rupture 4 5.00 Pain 1 5.00 Bone Cancer 1 5.00 Targeted Disruption 1 5.00 Death 1 5.00 Necrosis 1 5.00 Amputation 1 5.00 Cadaver 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

None of EGF, FGF and PDGF had a significant effect on ADAMTS-1 mRNA expression (Fig. 6A), but each induced significant decreases in ADAMTS-5 mRNA levels (P < 0.01, except for PDGF P < 0.05), which were maintained over 48 h (Fig. 6C).

PDGF Neg (12078) Binding (None) of Regulation (effect) of Gene_expression (expression) of ADAMTS-1 mRNA

1) Confidence 0.06 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.14

General Comments

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