INT238442

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 95.56 Very High Very High Very High
agonist 25 88.64 High High
cINOD 8 81.92 Quite High
Crohn's disease 1 71.20 Quite High
COX2 2 50.72 Quite High
Pain 1 12.00 Low Low
dexamethasone 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 100.00 Very High Very High Very High
INFLAMMATION 42 95.56 Very High Very High Very High
Inflammatory Bowel Disease 10 92.92 High High
Obesity 107 92.20 High High
Diabetes Mellitus 35 91.20 High High
Disorder Of Lipid Metabolism 4 90.64 High High
Apoptosis 30 87.12 High High
Dyslipidemia /

Combined Dyslipidemia

3 72.48 Quite High
Disease 47 71.20 Quite High
Cancer 37 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that mice with a targeted disruption of the PPAR?
Regulation (targeted) of Transcription (disruption) of PPAR associated with targeted disruption
1) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.67 Pain Relevance 0.40
Although a direct control of PPAR transcription is limited
Regulation (control) of Transcription (transcription) of PPAR
2) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.65 Pain Relevance 0.31
2821T may alter transcription of PPAR?
Regulation (alter) of Transcription (transcription) of PPAR
3) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.19 Pain Relevance 0
across the genome, and to understand the transcriptional regulation of PPAR?
Regulation (regulation) of Transcription (transcriptional) of PPAR
4) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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