INT238615

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 99.52 Very High Very High Very High
GABAergic 2 31.76 Quite Low
tetrodotoxin 20 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 58.72 Quite High
Adhesions 12 5.00 Very Low Very Low Very Low
Cleft Palate 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then wondered whether the CASK protein 4.1–binding site is also required for spinogenesis.
Spec (whether) Positive_regulation (required) of CASK Binding (binding) of
1) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
In addition to spinogenesis, CASK also acts presynaptically to regulate synaptogenesis through a different mechanism: CDK5 phosphorylates residues S51 and S395 of CASK proteins, which enhances the interaction between CASK and N-type calcium channels but impairs the interaction between CASK and liprin-?
Positive_regulation (enhances) of CASK Binding (interaction) of associated with calcium channel
2) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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