INT238858

Context Info Confidence 0.08 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.18 Pain Relevance 0.14

cytosol (GK) mitochondrion (GK) small molecule metabolic process (GK) carbohydrate metabolic process (GK) cytoplasm (GK)

Anatomy Link Frequency muscle cells 1 liver 1 GK (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 38 86.44 tolerance 1 27.36 Catecholamine 4 5.00 cytokine 2 5.00 anesthesia 2 5.00 Inflammatory response 2 5.00 Pain 2 5.00 Bile 2 5.00 COX2 1 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Muscular Dystrophy 17 100.00 Disorder Of Lipid Metabolism 2 99.60 Diabetes Mellitus 36 99.22 Syndrome 5 84.32 Turner's Syndrome 2 82.72 Convulsion 1 81.16 Ketoacidosis 1 80.64 Hypoglycemia 1 80.08 Bone Cancer 1 79.48 Dementia 1 78.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, glycerol kinase expression has been demonstrated in human muscle cells (29).

Gene_expression (expression) of glycerol kinase in muscle cells

1) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.38 Pain Relevance 0

In particular, cocultured NPI showed a statistically significant increase of the expression of PDX-1, Glucokinase (GK), and GLUT-2 as compared to controls (P < .050). 3.4.

Gene_expression (expression) of GK

2) Confidence 0.06 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0

X-linked conditions, such as AHC, GKD and DMD, are usually found only in males since females can express sufficient levels of protein from the genes on their active X chromosome.

Gene_expression (express) of GKD associated with muscular dystrophy

3) Confidence 0.04 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 1.07 Pain Relevance 0

Analysis of 42 genes associated with diabetes by RT q-PCR showed that in the liver, expression of Gk, Glut-2, apolipoprotein A-IV (ApoA-IV), PPAR?

Gene_expression (expression) of Gk in liver associated with diabetes mellitus and disorder of lipid metabolism

4) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.72 Pain Relevance 0.14

General Comments

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