INT238864

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.39
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPL) small molecule metabolic process (LPL) extracellular region (LPL)
plasma membrane (LPL) lipid metabolic process (LPL)
Anatomy Link Frequency
Adipose tissue 4
liver 2
monocytes 2
lipid droplets 2
LPL (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 40 96.56 Very High Very High Very High
Inflammation 23 77.04 Quite High
antagonist 2 60.72 Quite High
chemokine 3 49.92 Quite Low
cytokine 24 47.16 Quite Low
Inflammatory stimuli 2 12.64 Low Low
Bile 9 5.00 Very Low Very Low Very Low
Catecholamine 8 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 234 100.00 Very High Very High Very High
Stress 5 99.24 Very High Very High Very High
Disorder Of Lipid Metabolism 14 94.80 High High
Apoptosis 6 84.12 Quite High
INFLAMMATION 28 77.04 Quite High
Infection 2 23.00 Low Low
Congenital Anomalies 2 5.80 Low Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some cells were partially able to overcome the effects of ouabain depolarization at later time points, as seen by their ability to increase LPL expression and form lipid droplets.


Positive_regulation (increase) of Gene_expression (expression) of LPL in lipid droplets
1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Positive_regulation (Adipose) of Gene_expression (cause) of LPL in Adipose tissue associated with obesity
2) Confidence 0.15 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.85 Pain Relevance 0
Expression of Lpl in liver is restricted to Kupffer cells and upregulated by PPAR?
Positive_regulation (restricted) of Gene_expression (Expression) of Lpl in liver
3) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.33 Pain Relevance 0.19
Adipose tissue lipoprotein lipase (LPL)-mediated TAG hydrolysis might be the cause of an increased net TAG extraction during ?
Positive_regulation (Adipose) of Gene_expression (cause) of tissue lipoprotein lipase in Adipose tissue associated with obesity
4) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.85 Pain Relevance 0
Thus, leptin was shown to stimulate the oxidative burst in control monocytes [32], and binding of leptin at the macrophage cell surface increases lipoprotein lipase expression through oxidative stress- and PKC-dependent pathways.
Positive_regulation (increases) of Gene_expression (expression) of lipoprotein lipase in monocytes associated with stress
5) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

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