INT239036

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.44
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-DMA) intracellular (HLA-DMA) protein complex assembly (HLA-DMA)
Anatomy Link Frequency
neutrophil 1
HLA-DMA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 98.12 Very High Very High Very High
rheumatoid arthritis 106 87.36 High High
Potency 18 86.32 High High
Inflammation 35 73.92 Quite High
chemokine 5 26.36 Quite Low
Arthritis 31 6.48 Low Low
Inflammatory response 8 5.80 Low Low
Paracetamol 15 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
abatacept 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 39 93.96 High High
Rheumatoid Arthritis 106 87.36 High High
Death 50 84.36 Quite High
Hypercalcemia 1 80.80 Quite High
Chromosome Aberrations 3 79.24 Quite High
Lymphatic System Cancer 3 76.68 Quite High
INFLAMMATION 38 73.92 Quite High
Sprains And Strains 12 69.60 Quite High
Bacterial Respiratory Disease 6 68.48 Quite High
Hyperplasia 10 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After prolonged exposure to lactic acid bacteria, CD74 and HLA-DMA and -B were upregulated.
Positive_regulation (upregulated) of HLA-DMA
1) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.23 Pain Relevance 0
When these compounds were tested for HPRT mutagenicity, both the N-hydroxy and aminophenol of 3,5-DMA were clearly mutagenic but these derivatives of 2,6-DMA were not active over the same range of dose levels (64).
Neg (not) Positive_regulation (active) of DMA
2) Confidence 0.09 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.08 Pain Relevance 0.04
N-hydroxy-2,6-DMA, the proposed product of metabolic activation of 2,6-DMA in vivo, was mutagenic in S.typhimurium TA100 (62) and was the most mutagenic member of a series of N-hydroxylated aniline derivatives in the absence of metabolic activation (30,63).
Positive_regulation (activation) of DMA
3) Confidence 0.08 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.23 Pain Relevance 0
N-hydroxy-2,6-DMA, the proposed product of metabolic activation of 2,6-DMA in vivo, was mutagenic in S.typhimurium TA100 (62) and was the most mutagenic member of a series of N-hydroxylated aniline derivatives in the absence of metabolic activation (30,63).
Positive_regulation (activation) of DMA
4) Confidence 0.08 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.22 Pain Relevance 0
The HLA-DMA TM receptor was among the class II receptors that were upregulated after 6 h exposure to L. plantarum WCFS1.
Positive_regulation (upregulated) of HLA-DMA TM receptor
5) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.07 Pain Relevance 0
IL-17 has pleiotrophic effects on many cell types including macrophages, fibroblasts, epithelial cells, endothelial cells and mesenchymal cells, where it induces upregulation of nuclear factor kappa B and HLA class I as well as neutrophil chemo-kines and cytokines such as TNF?
Positive_regulation (upregulation) of HLA in neutrophil associated with cytokine
6) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.61 Pain Relevance 0.36

General Comments

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