INT239227

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca, Nos3) cytoplasm (Prkca, Nos3) nucleus (Prkca, Nos3)
plasma membrane (Prkca, Nos3) Golgi apparatus (Nos3) endoplasmic reticulum (Prkca)
Prkca (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
Angina 2 62.48 Quite High
Inflammation 29 23.60 Low Low
bradykinin 10 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 6 99.20 Very High Very High Very High
Diabetes Mellitus 36 95.60 Very High Very High Very High
Stress 10 94.72 High High
Disease 4 71.44 Quite High
Stable Angina Pectoris 1 62.48 Quite High
Death 2 56.68 Quite High
Increased Venous Pressure Under Development 37 43.28 Quite Low
INFLAMMATION 28 23.60 Low Low
Insulin Resistance 2 19.04 Low Low
Atherosclerosis 2 18.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In presence of hyperglycemia high levels of diacylglycerol activate PKC which in turn induces alterations of eNOS activity and NADPH oxidase, and then contributes to an elevated production of free oxygen radicals and to an increase in oxidative stress (Hink et al 2001).
PKC Regulation (alterations) of eNOS associated with stress, hyperglycemia and kinase c
1) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.97 Pain Relevance 0.20

General Comments

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