INT239307

Context Info Confidence 0.24 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.17

endosome (Abcg1) transport (Abcg1) Golgi apparatus (Abcg1) ATPase activity (Abcg1) plasma membrane (Abcg1) intracellular (Abcg1)

Abcg1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 15 94.56 Inflammation 9 77.20 alcohol 11 5.00 Bile 4 5.00 Angina 3 5.00 ischemia 2 5.00 cytokine 1 5.00 Nicotine 1 5.00 imagery 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 288 93.64 Diabetes Mellitus 3 89.64 Vasculitis 1 77.20 Atherosclerosis 49 74.72 Disease 5 73.44 Hyperlipidemia 2 55.64 Targeted Disruption 10 29.84 INFLAMMATION 8 15.64 Coronary Heart Disease 33 5.00 Myocardial Infarction 19 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

mediate activation of the LXR/RXR heterodimer, which in turn regulates cholesterol efflux via ABCA1 and ABCG1 activation (Schmitz et al 2002).

Positive_regulation (activation) of ABCG1

1) Confidence 0.24 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.73 Pain Relevance 0.17

General Comments

This test has worked.