INT239333

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.29 Pain Relevance 0.03

endosome (Abcg1) transport (Abcg1) Golgi apparatus (Abcg1) ATPase activity (Abcg1) plasma membrane (Abcg1) intracellular (Abcg1)

Abcg1 (Mus musculus) RCT (Mus musculus)

Pain Link Frequency Relevance Heat agonist 15 52.24 alcohol 11 5.00 Inflammation 9 5.00 Bile 4 5.00 Angina 3 5.00 ischemia 2 5.00 cytokine 1 5.00 Nicotine 1 5.00 imagery 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 288 100.00 Targeted Disruption 10 84.20 Atherosclerosis 49 77.08 Atherosclerotic Plaque 3 68.92 Insulin Resistance 2 59.20 Metabolic Syndrome 1 57.04 Hypolipidemia 2 39.72 Coronary Heart Disease 33 5.00 Myocardial Infarction 19 5.00 Cardiovascular Disease 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, these data suggest that both ABCA1 and ABCG1 are potential therapeutic targets to raise HDL-C and promote RCT.

ABCG1 Positive_regulation (promote) of RCT associated with disorder of lipid metabolism

1) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.29 Pain Relevance 0.03

General Comments

This test has worked.