INT239489

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1) cytoskeleton (Spna1)
molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
joints 1
Spna1 (Mus musculus)
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 28 99.08 Very High Very High Very High
metalloproteinase 1 86.44 High High
Pain 6 75.68 Quite High
analgesia 1 57.04 Quite High
Osteoarthritis 1 50.00 Quite Low
Analgesic 1 39.16 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 30 99.08 Very High Very High Very High
Pain 5 75.68 Quite High
Disease 5 55.96 Quite High
Osteoarthritis 1 50.00 Quite Low
Hyperplasia 5 8.16 Low Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Synovitis 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether the injected HA in the present joints may act to reduce TIMP-1 levels, allowing uninhibited MMP activity to counteract the effects of CTGF and thus decrease fibrosis requires further investigation.
HA Negative_regulation (reduce) of TIMP-1 in joints associated with fibrosis
1) Confidence 0.00 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.89 Pain Relevance 0.57

General Comments

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